Hyponatremia in Patients Receiving Psychotropic Drugs: Prevalence and Its Management
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Abstract
Introduction: Hyponatremia is defined as serum sodium below 135 mEq/L. Hyponatremia is a common electrolyte disorder in psychiatric patients. Factors affecting are the use of psychotropic drugs and other factors such as gender, age, underlying diseases, etc. Objectives: To study the prevalence of hyponatremia in patients receiving psychiatric drugs and study the guidelines for managing hyponatremia in psychiatric patients that takes psychiatric drugs. Materials and Methods: This study was retrospective cross-sectional study. Data collection was conducted in psychiatric inpatients at Prasrimahabhodi psychiatric hospital using medical records from January 1, 2017 to December 31, 2018. Results: Psychiatric inpatient with serum sodium measurement in study period were 2,257 and 199 patients had hyponatremia. The prevalence of hyponatremia in patients receiving psychotropic drugs was 3.32% (84/2527). Psychotropic drugs that associated with hyponatremia including First generation antipsychotics, Second generation antipsychotics, Mood Stabilizers, Selective serotonin reuptake inhibitors, Atypical Antidepressants, Tricyclic antidepressants. The main strategy for management of psychotropic drugs-induced hyponatremia was follow sign and symptoms without discontinuation drug. Conclusions: the prevalence of hyponatremia in patients receiving psychotropic drugs was 3.32 and almost all psychotropic drugs can cause hyponatremia.
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ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
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