Factors that influcence the major bleeding in various patients on chronic warfarin therapy

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Uthai Phengtham


Warfarin has been used extensively as an anticoagulant for a variety of disease. The factors that influence the major bleeding
in various patients on chronic warfarin therapy were studied. A retrospective cohort study was conducted on patients who were
being seen in outpatient clinics. The record of 382 patients were reviewed. It has been founded that 54 patients had major bleeding.
Factors that influcnce the major bleeding were history of previous bleeding for 11 cases (IRR = 4.06% ; 95% Cl, 1.93 - 8.57) p <
0.001 and aspirin for 5 cases (IRR = 2.635 ; 95% Cl = 1.03 - 6.69) p < 0.042. In conclusion, the history of previous bleeding and
aspirin were factors that influnce the major bleeding, physician ahould monitors these factors closely in patients who had been
on wafarin therapy to prevent risk of major bleeding.


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How to Cite
Phengtham, U. . . (2022). Factors that influcence the major bleeding in various patients on chronic warfarin therapy. Lampang Medical Journal, 29(1), 59–66. Retrieved from https://he01.tci-thaijo.org/index.php/LMJ/article/view/259958
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