Chloroquine Maculopathy in Chiang Rai Regional Hospital

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Sarintip Thongsiw


Background: Maculopathy is the most serious ophthalmic adverse event of chloroquine and causes permanent visual loss. Many previous studies showed the association between chloroquine maculopathy and several risk factors, but the conclusion was unclear.
Objective: To study the incidence and risk factors of chloroquine maculopathy in Chiang Rai Regional Hospital.
Material and method: An analytic cross-sectional study was conducted on 51 out-patients who received chloroquine for their treatment and had eye examination in Chiang Rai Regional Hospital during 1st January – 31st December 2009. The data was retrospectively collected; including age, gender, cumulative dose, duration of treatment and examination results. The data was analyzed by descriptive statistics, t- test and Mann-Whitney U test.
Results: Most of the patients were female (88.2%). The mean age was 49.6 ± 13.7 years (range, 14-83). The mean duration of treatment was 48.8 ± 36.4 months (range, 7-168). The mean cumulative dose was 336.9 ± 226 grams (range, 53-1260). All of the patients had fundoscopic examination under slit lamp and +78 D lens. Color test was performed in 35 patients whereas
only half had visual field examination. Cornea verticilata was found in 7 patients. Sixteen patients (31.4%) were diagnosed as chloroquine maculopathy. There was no statistical difference in age, cumulative dose and duration of treatment between normal group and maculopathy group (p=0.47, 0.19 and 0.22 respectively).
Conclusion: Chloroquine maculopathy was not associated with age, cumulative dose and duration
of treatment


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How to Cite
Thongsiw, S. . (2022). Chloroquine Maculopathy in Chiang Rai Regional Hospital. Lampang Medical Journal, 31(3), 98–104. Retrieved from
Original Article


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