Results of Penetrating Keratoplasty in Phrae Hospital

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Surarak Weerattanatpong


Background: Penetrating keratoplasty (PKP) is a surgery for blindness from corneal diseases. Results of PKP in Phrae Hospital have not been studied.

Objective: To determine the results of PKP in Phrae Hospital using corneal cutting techniques by manual and vacuum trephines.

Material and method: A retrospective cohort study was conducted among patients with corneal diseases who underwent optical PKP in Phrae Hospital by single ophthalmologist. Patients in group 1 underwent
surgery during 2007 – 2010, using manual trephine for corneal cutting and donor corneas from the local donation campaign. Group 2 underwent surgery during 2018 – 2019, cutting cornea by vacuum trephine and
receiving donor cornea from the Thai Red Cross Eye Bank and local donation campaign. The follow-up period was at least one year. Visual outcomes and complications were compared between groups using
Mann-Whitney U test and Fisher’s exact test.

Results: PKPs were performed in 19 eyes of 17 patients (1 case bilaterally, 1 case redo surgery) and nine cases were male. The mean age was 66.2 (SD 10.9) years (range 42–80). Herpes simplex keratitis was
the most common disease. Group 1 (8 eyes) underwent PKP in 5, triple operation in 2 and PKP with scleral-fix IOL in 1 eye respectively. Group 2 (11 eyes) underwent triple operation in 6, PKP in 4 and PKP with IOL
exchange in 1 eye respectively. Most of the patients had postoperative visual acuity at 6/24 – 6/60. Seven eyes in group 1 and eight eyes in group 2 had better visual outcomes (p=0.426). Regarding to the remaining
clear corneal grafts postoperatively, the success rate was 75% in group 1 at 2-year and 72.7% in group 2 at 1-year follow-up (p=0.664). Most of complications were astigmatism (6 vs 5 eyes in group 1 and 2 respectively,
(p=0.208), glaucoma (5 eyes) and graft failure (3 eyes).

Conclusion: The success rate of PKP in Phrae Hospital was 73.7%. Most of the patients had better visual outcomes. Herpes simplex keratitis was the most common etiology. The major complication was astigmatism
which more commonly found in cases using manual trephine.


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Weerattanatpong, S. . (2021). Results of Penetrating Keratoplasty in Phrae Hospital. Lampang Medical Journal, 42(1), 9–20. Retrieved from
Original Article


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