Safety and clinical outcomes of Transcatheter Device Closure of Atrial Septum Defect in Adults at Lampang Hospital

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Yotsawee Chotechuang


Background: Atrial septal defect (ASD) is a common congenital heart disease in adults. Transcatheter device closure of ASD secundum type (TC-ASD) is a standard treatment and has been implemented at Lampang Hospital since 2015.
Objective: To determine safety and clinical outcomes of adult patients after receiving TC-ASD at
Lampang Hospital.
Material and method: A retrospective cohort study was conducted among patients over 18 years of age, diagnosed with ASD secundum type, who underwent TC-ASD with the Cocoon septal occulder devices at Lampang Hospital between July 2015 and September 2018. The complications and clinical outcomes were recorded and statistically compared at 1, 6 and 12 months of follow-ups.
Results: There were 29 patients with the mean age of 55.5 ± 13.8 years (range 21-81). Twenty cases were female (69%). The mean size of ASD measured by transthoracic echocardiography (TTE) was 19.9 ± 5.1 mm (range 12-29). The mean size of ASD closure device was 27.4 ± 4.9 mm (range 6-36). The success rate of the procedure was 100%. One patient (3.5%) had a residual ASD shunt at 1 month and spontaneous closure at 6 months. Significant improvement of TTE parameters after 1-month included right ventricular diastolic diameter, tricuspid regurgitation pressure and right ventricular systolic pressure. The mean pulmonary arterial pressure was significantly decreased at 12 months. No major complications were observed. One patient (3.5%) developed supraventricular tachycardia at 6-month and received radiofrequency ablation. All patients had functional class improvement to NYHA 1 at 1, 6 and 12 months of follow-ups (p<0.001).
Conclusion: TC-ASD in adult patients is safe and effective in terms of clinical improvement and significant reduction of TTE parameters after 1-12 months after the procedure.


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Chotechuang, Y. (2020). Safety and clinical outcomes of Transcatheter Device Closure of Atrial Septum Defect in Adults at Lampang Hospital. Lampang Medical Journal, 40(2), 41–49. Retrieved from
Original Article


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