Effects of Lotion Containing Freeze-Dried Aloe Vera Extract on Elderly Skin in Pathum Thani Province
Keywords:
aloe vera, freeze dry, skin moisture, transepidermal water lossAbstract
The objectives of this quasi-experimental research were (1) to study the antioxidant activity of freeze-dried aloe vera extract, (2) to develop a lotion product containing freeze-dried aloe vera extract that is stable, and (3) to study the results of using lotion products containing freeze-dried aloe vera extract. The sample groups consisted of 60 elderly men and women with dry skin, divided into 30 control groups and 30 experimental groups. Data were collected by measuring skin moisture levels and transepidermal water loss of skin after using the lotion for 4 weeks. Data were analyzed using descriptive statistics and statistics comparing means between two independent sample groups. The results of the study found that (1) freeze-dried aloe vera extract at concentrations of 6–200 micrograms per milliliter had antioxidant activity of 16.43–66.22% with an IC50 value of 143.92 micrograms per milliliter. (2) Lotion products containing freeze-dried aloe vera extract have good stability. (3) The results of the efficiency test after using the lotion product containing freeze-dried aloe vera extract found that the experimental group had an average skin moisture level of 34.24, which was significantly increased at the .05 level. For the transepidermal water loss of skin, the experimental group had a transepidermal water loss value of 6.82, which was significantly decreased at the .05 level. The results of this study conclude that lotion products containing freeze-dried aloe vera extract have good stability and have an effect on the skin of the elderly in terms of increasing skin moisture and decreasing skin transepidermal water loss. This can be used as a guideline to develop the natural health products to add value and further commercialization.
References
Djawad, K., & Anggraini, D. (2021). The effectiveness of Oral Superoxide Dismutase (SOD) on total antioxidant status, Transepidermal Water Loss (TEWL) and sebum concentration in photo aging skin. Medical science of Ukraine, 17(1), 47-56. https://doi.org/10.32345/2664-4738.1.2021.06
Dobos, G., Trojahn, C., Lichterfeld, A., D Alessandro, B., Patwardhan, S. V., Canfield, D., Blume-Peytavi, U., & Kottner, J. (2015). Quantifying dyspigmentation in facial skin ageing: An explorative study. International Journal of Cosmetic Science, 37(5), 542–549. https://doi.org/10.1111/ics.12233
Hajheydari, Z., Saeedi, M., Morteza-Semnani, K., & Soltani, A. (2014). Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial. The Journal of Dermatological Treatment, 25(2), 123–129. https://doi.org/10.3109/09546634.2013.768328
Hosseinimehr, S. J., Khorasani, G., Azadbakht, M., Zamani, P., Ghasemi, M., & Ahmadi, A. (2010). Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats. Acta Dermatovenerologica Croatica: ADC, 18(1), 2–7. PMID: 20361881
García, M. H., Juárez, J. A. T., & Jiménez, A. D. (2019). Importance and properties of aloe vera in the production of hair shampoo. The Journal of Middle East and North Africa Sciences, 5(7), 18-23. https://bit.ly/3O1fKBe
Gkogkolou, P., & Böhm, M. (2012). Advanced glycation end products: Key players in skin aging?. Dermato-Endocrinology, 4(3), 259–270. https://doi.org/10.4161/derm.22028
Gomes-Rochette, N. F., Da Silveira Vasconcelos, M., Nabavi, S. M., Mota, E. F., Nunes-Pinheiro, D. C., Daglia, M., & De Melo, D. F. (2016). Fruit as potent natural antioxidants and their biological effects. Current Pharmaceutical Biotechnology, 17(11), 986–993. https://doi.org/10.2174/1389201017666160425115401
Kancheva, V. D., & Kasaikina, O. T. (2013). Bio-antioxidants - a chemical base of their antioxidant activity and beneficial effect on human health. Current Medicinal Chemistry, 20(37), 4784–4805. https://doi.org/10.2174/09298673113209990161
Katta, R., Sanchez, A., & Tantry, E. (2020). An anti-wrinkle diet: Nutritional strategies to combat oxidation, inflammation and glycation. Skin therapy letter, 25(2), 3–7. PMID: 32196147
K Green, A. C., Hughes, M. C., McBride, P., & Fourtanier, A. (2011). Factors associated with premature skin aging (photoaging) before the age of 55: A population-based study. Dermatology (Basel, Switzerland), 222(1), 74–80. https://doi.org/10.1159/000322623
Krutmann, J., Bouloc, A., Sore, G., Bernard, B. A., & Passeron, T. (2017). The skin aging exposome. Journal of Dermatological Science, 85(3), 152–161. https://doi.org/10.1016/j.jdermsci.2016.09.015
Lee, C. M., Watson, R. E. B., & Kleyn, C. E. (2020). The impact of perceived stress on skin ageing. Journal of the European Academy of Dermatology and Venereology: JEADV, 34(1), 54–58. https://doi.org/10.1111/jdv.15865
Leung, M. H. Y., Tong, X., Bastien, P., Guinot, F., Tenenhaus, A., Appenzeller, B. M. R., Betts, R. J., Mezzache, S., Li, J., Bourokba, N., Breton, L., Clavaud, C., & Lee, P. K. H. (2020). Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants. Microbiome, 8(1), 100. https://doi.org/10.1186/s40168-020-00874-1
Lim, K. M. (2021). Skin epidermis and barrier function. International Journal of Molecular Sciences, 22(6), 3035. https://doi.org/10.3390/ijms22063035
Naylor, E. C., Watson, R. E., & Sherratt, M. J. (2011). Molecular aspects of skin ageing. Maturitas, 69(3), 249–256. https://doi.org/10.1016/j.maturitas.2011.04.011
Raeisi Estabragh, M. A., Sajadi Bami, M., Dehghannoudeh, G., Noudeh, Y. D., & Moghimipour, E. (2023). Cellulose derivatives and natural gums as gelling agents for preparation of emulgel-based dosage forms: A brief review. International Journal of Biological Macromolecules, 241, 124538. https://doi.org/10.1016/j.ijbiomac.2023.124538
Schikowski, T., & Hüls, A. (2020). Air pollution and skin aging. Current Environmental Health Reports, 7(1), 58–64. https://doi.org/10.1007/s40572-020-00262-9
Sawaddichai, C., Im-iam, S., Saensanoh, S., Inthawattana, W., & Chaiyamongkol, K. (2018). Aloe vera. The Journal of Prapokklao Hospital Clinical Medical Education Center, 35(3), 324-328. (in Thai)
Sillaparassamee, R., Jaricksakulchai, J., & Sawangaleerat, R. (2022). Effect of organic agriculture wastes Sandoricum koetjape for health product development anti–oxidation to commercialization, Sa Kaeo Province. EAU Heritage Journal Science and Technology, 17(1), 103-112. (in Thai)
Tangjitjareonkun, J., & Supabphol., R. (2015). Application of Aloe vera on wound healing. Journal of Medicine and Health Sciences, 22(3), 53-67. (in Thai)
