Patients with Early Stage of Hormone Estrogen Receptor Positive Breast Cancer and Self-care
Keywords:
Breast cancer in early stage, estrogen receptor positive, self-care, patientAbstract
Breast cancer is the most common cancer in the world, including in Thailand, where breast cancer in the early stages is stage 0-2, which can be cured and has a 5-year disease-free period of about 80–90 percent. Therefore, early detection is important for patient survival. Moreover, appropriate diagnosis of the pathology of cancer cells is a base for therapeutic plans. The main treatment is tumor removal, and Sentinel Lymph Node Biopsy--SLNB is a benefit to prevent lymphedema in patients without metastasis. The survival rates of Breast Conserving--BCS with radiation and a mastectomy are not different. After that, adjuvant therapies to prevent recurrences were considered, such as chemotherapy, radiotherapy, and anti-hormonal drugs for 5 years. Tamoxifen is effective for premenopausal women, and Aromatase Inhibitors--AIs are for postmenopausal women. Moreover, adding OFS with Tamoxifen or AIs will be beneficial for high-recurrence patients. Planning pregnancy after breast cancer treatment should be discussed before starting treatment. Genetic counseling should be provided for BRCA1/BRCA2 gene-positive individuals. Most patients are able to stay at home during long-term treatment; however, proper self-care will be done to manage serious side effects such as decreased immunity after chemotherapy and endometrial cancer after Tamoxifen. The patients need to take care of themselves to be strong both physically and mentally for effective treatment and a good quality of life.
References
Abdel-Razeq, H. (2019). Gonadotropin-releasing hormone agonists during chemotherapy for ovarian function and fertility preservation for patients with early-stage breast cancer. Cancer ManagementResearch, 11, 4273–4282. https://doi.org/10.2147/CMAR.S204069
American Cancer Society. (2023). Breast-cancer-hormone-receptor-status. Retrieved from https://www.cancer.org
American Society. (2022). Pregnancy after breast cancer. Retrieved from https://www.cancer.org
American Cancer Society, (2021). Possible side effects of chemo for breast cancer. Retrieved from https://www.cancer.org
American Cancer Society. (2019). Cancer facts & figures or African Americans 2019-2021. Retrieved from https://www.cancer.org.
Berliner, J. L., Fay, A. M., Cummings, S. A., Burnett, B., & Tillmanns, T. (2013). NSGC practice guideline: Risk assessment and genetic counseling for hereditary breast and ovarian cancer. Journal of Genetic Counsulation, 22(2), 155-63. https://doi.org/10.1007/s10897-012-9547-1
Breastcancer. (2022). Drugs for treatment and reduction: Zoladex. Retrieved from https://www.breastcancer.org
Centers for Disease Control and Prevention (CDC). (2019). Genetic Testing for Hereditary Breast and Ovarian Cancer. Retrieved from https://www.cdc.gov
Choi, L. (2022). Breast cancer pathology. Retrieved from https://www.msdmanuals.com
Chula Cancer. (2023). Self-care for thoracic radiotherapy patients. Retrieved from https://www.chulacancer.net (in Thai)
DiPiro, C. V. (2015). Oncologic Diorders, Pharmacotherpy handbook (9th ed.). New York: Mc Graw Hill Education.
Gillespie, T. C., Sayegh, H. E., Brunelle, C. L., Daniell, K. M., & Taghian, A. G. (2018). Breast cancer-related lymphedema: Risk factors, precautionary measures, and treatments. Gland Surgery, 7(4), 379-403. https://doi.org/10.21037/gs.2017.11.04
Hilal-Dandan, R., & Brunton, L. L. (2014). Estrogen and Progestin. Goodman & Gilman’s: The manual of Pharmacology and Therapeutics (2nd ed.). New York: Mc Graw Hill Education.
Imsumran, W., Chaiweerawatthana, A., Manorom, D., & Thasitthichai, S. (2017). Screening guidelines diagnose and treat breast cancer, Ministry of Public Health, Kosit. Bangkok: Ministry of Public Health (in Thai)
Kuuppelomaki, M. & Lauri, S. (1998). Cancer patients’ reported experiences of suffering.Cancer Nursing, 21(5), 364-349. https://doi.org/10.1097/00002820-199810000-00008
Litière, S., Werutsky, G., Fentiman, I. S., Rutgers, E., Christiaens, M. R., Van Limbergen, E., Baaijens, M. H., Bogaerts, J., & Bartelink, H. (2012). Breast conserving therapy versus mastectomy for stage I-II breast cancer: 20 year follow-up of the EORTC 10801 phase 3 randomized trial. Lancet Oncology, 13, 412–419. https://doi.org/10.1016/S1470-2045(12)70042-6
Lu, Y., Wong, A., & Kim, H., (2021). Ovarian function suppression with Luteinizing Hormone-Releasing Hormone Agonists for the treatment of hormone receptor-positive early breast cancer in premenopausal Women. Frontiers in Oncology, 11, 1-15. https://doi.org/10.3389/fonc.2021.700722
Maha Vashiralongkorn Thanyaburi Hospital, (2022). Hand out for self-care Chemotherapy Patient. McCormack, V., McKenzie, F., Foerster, M., Zietsman, A., Galukande, M., Adisa, C., Anele, A., Parham, G., Pinder, L.F., Cubasch, H., Joffe, M., Beaney, T., Quaresma, M., Togawa, K., Abedi-Ardekani, B., Anderson, B. O., Schüz, J., & Dos-Santos-Silva, I. (2020). Breast cancer survivaland survival gap apportionment in Sub-Saharan Africa (ABC-DO): A prospective cohort study. The Lancet Global Health, 8(9), e1203–e1212. https://doi.org/10.1016/S2214-109X(20)30261-8
Moffatt, C. J., Franks, P. J., Dohert, D. C., Williams, A. F., Badge, C., Jeffs E., Bosanquet, N., & Mortimer P.S. (2003). Lymphoedema: An underestimated health problem. QJM: An Internatinal Journal of Medicine, 96(10), 731–8. https://doi.org/10.1093/qjmed/hcg126.
National Cancer Institute. (2023). Breast cancer treatment (PDQ®)–Health professional version. Retrieved from https://www.cancer.gov.
National Cancer Institute. (2023). Recommendation for Gene BRCA1/BRCA2 examination in breast cancer patients and direct relative with mutation gene. Retrieved from https://nci.go.th (in Thai)
National Cancer Institute. (2021). Hospital based cancer registry 2021. Retrieved from http://www.nci.go.th. (in Thai)
National Cancer Institute. (2017). CPG for breast cancer screening and treatment. Retrieved from https://nci.go.th. (in Thai)
Ramachanel, Faculty of Medicine Ramathibodi Hospital Mahidol University. (2023). How to care after breast cancer surgery. Retrieved from https://www.rama.mahidol.ac.th. (in Thai)
Promkamsao, N., Thongkrajai, E., & Tangworaphongchai, J. (2015). Experience of young women with breast cancer. Journal of Nursing Science & Health, 38(2), 86-94. (in Thai)
Sancarn, T., & knkthes, T. (2019). Breast cancer literacy in prevention and breast self-examination. EAU Heritage Journal Science and Technology, 13(3), 14–21. (in Thai)
Sinthuwongsanon, D. (2015). The Integration of caring for the end-of-life stage cancer patients by the application of Buddhadhamma in Theravada Buddhasasana. The Journal of Boromarajonani College of Nursing, Nakhonratchasima, 21(1),54-64. (in Thai)
Singer, S., Blettner, M., Kreienberg, R., Janni, W., Wöckel, A., Kühn, T., Felberbaum, R., Flock, F., Schwentner, L., & BRENDA II study group. (2015). Breast cancer patients’ fear of treatment: Results from the multicenter longitudinal study BRENDA II. Breast care (Basel, Switzerland), 10(2), 95–100. https://doi.org/10.1159/000381933
Sung, H., Ferlay, J., & Siegel, R. L. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. A Cancer Journal for Clinicians, 71, 209-249. https://doi.org/10.3322/caac.21660
Thai Health Promotion Foundation, Ministry of Public health. (2021). Thai health report 2021. Retrieved from http://www.infocenter.nationalhealth.or.th (in Thai)
Thai Breast Society. (2023). Signs and symptoms of breast cancer. Retrieved from https://www.thaibreast.org. (in Thai)
Thanyarak center, Siriraj Hospital. (2022). Clinical Practice Guidelines (CPG) for diagnosis and treatment of breast cancer. Retrieved From https://thanyarak.or.th (in Thai)
Xiang, W., Wu, C., Wu, H., Fang, S., Liu, N., & Yu, H. (2022). Survival comparisons between breast conservation surgery and mastectomy followed by postoperative radiotherapy in stage I–III breast cancer patients: Analysis of the surveillance, epidemiology, and end results (Seer) program database. Current Oncology, 29(8), 5731–5747. https://doi.org/10.3390/curroncol29080452
Yi, A., Kim, H. H., Shin, H. J., Huh, M. O., Ahn, S.D., & Seo, B. K. (2009). Radiation-induced complications after breast cancer radiation therapy: A pictorial review of multimodality imaging findings. Korean Journal of Radiology, 10(5), 496–507. https://doi.org/10.3348/kjr.2009.10.5.496
Yottavee, W., Kaewkong, N., LowThumma, P., Chidnayee, S., Chaiwongnakpun, C., & Tummee, S. (2019). Adaptation of Woman with Breast Cancer. Boromarajonani College of Nursing, Uttaradit Journal, 11(2), 272-283. (in Thai)
