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This research was composed of two-group quasi-experimental research (Two groups pretest-protest design) groups. This study aimed to determine the effect of applying the Transtheoretical Model to the change of smoking behavior of male high-school students in Dan Sai District, Loei Province. The sample was male high school students in Loei Province which were divided into 2 groups, 1 group of 35 experimental students and another group of 35 student for the control group. The samples were selected from each school by purposive sampling according to the criteria defined programs that were created in the period of 10 weeks, consisting of 6 activities including (1) modification of behavior; (2) awareness of the dangers of smoking; (3) knowledge that quitting smoking is more useful than smokers think; (4) planning for a contract to stop smoking; (5) encouragement towards goals and (6) stimulation control and successful outcome management. Data were collected by using a questionnaire. Data were analyzed by using descriptive statistics, paired t-test and Independent t-test statistics. The result found that the experimental group had an average score balanced decisions in changing smoking behavior which increased over baseline (p<.001) and higher than the control group (p<.001) with statistically significant level at the 0.05 level. Self-efficacy in changing smoking behavior was higher than before the experiment (p<.001) and higher than the control group (p<.001) with statistical significance at the .05 level. Smoking avoidance behavior increased over baseline (p<.001) and was higher than the control group (p=.002) which were significantly statistical at .05 level. Smoking behavior was lower than before the experiment (p<.001) and less than the control group (p<.001) with statistical significance level at the .05 level. The results of this study can be employed as the guidelines to reduce the smoking behavior in the groups of youths to encourage the students to quit smoking and prevent the emergence of new smokers.
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