Factors associated with stroke among adult patients with hypertension in La-ngu District, Satun Province
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Abstract
Background: Worldwide, stroke has become the major cause of mortality and morbidity among the population. Hypertension is one of the factors associated with stroke. Individuals with hypertension are at high risk of developing stroke. This study aimed to assess factors associated with stroke among patients with hypertension in La-ngu district, Satun province.
Methods: A retrospective study was conducted on 199 adult stroke patients selected by simple random sampling from patients admitted to the La-ngu Hospital Medical Center Stroke Unit from January 1, 2017 to December 31, 2021. Data were extracted from January to March 2022 and entered Epi-data v.3.1 and analyzed by R v.4.2. Variables with a p-value of less than 0.25 in the bivariate logistic regression were selected for multivariable logistic regression. The adjusted odds ratio and 95% confidence interval were used to determine the association. p-value < 0.05 was used to declare statistical significance.
Result: The mean age of stroke patients with hypertension and stroke patients without hypertension were 72.7 years (SD±13.60) and 66.7 years (SD±13.70) respectively. Aged 60 years and over (OR=1.9, p-value=0.046), diabetes (OR=4.0, p-value <0.001), fasting blood glucose is between 100 to 125 mg/dL (OR=4.1, p-value<0.001), Fasting blood glucose is 126 mg/dl or higher (OR=4.4, p-value <0.001), and eGFR between 30 and 59 (OR=3.2, p-value=0.008) were found to be significant factors.
Conclusions: Aged 60 years and over, diabetes, high blood sugar levels, and decreased glomerular filtration rate were associated with stroke among adult patients with hypertension
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References
Lo EH, Dalkara T, Moskowitz MAJNrn. Mechanisms, challenges and opportunities in stroke. 2003;4(5):399-414.
González RG, Hirsch JA, Koroshetz W, Lev MH, Schaefer PW. Acute ischemic stroke. New York: Springer; 2011.
World Stroke Organization. Up again after stroke. Available at: http://www.worldstrokecampaign. org. Accessed on 23 September 2021.
Health Data Center. Prevalence of stroke. Available at: https://hdcservice.moph.go.th/hdc/reports. Accessed on 1 October 2021.
Della-Morte D, Guadagni F, Palmirotta R, Testa G, Caso V, Paciaroni M, et al. Genetics of ischemic stroke, stroke-related risk factors, stroke precursors and treatments. 2012;13(5):595-613.
Guzik A, Bushnell CJCLLiN. Stroke epidemiology and risk factor management. 2017;23(1):15-39.
Boehme AK, Esenwa C, Elkind MSJCr. Stroke risk factors, genetics, and prevention. 2017;120(3):472-95.
Shou J, Zhou L, Zhu S, Zhang XJJoS, Diseases C. Diabetes is an independent risk factor for stroke recurrence in stroke patients: a meta-analysis. 2015;24(9):1961-8.
Renna, R., Pilato, F., Profice, P., Della Marca, G., Broccolini, A., Morosetti, R., ... & Di Lazzaro, V. (2014). Risk factor and etiology analysis of ischemic stroke in young adult patients. Journal of stroke and cerebrovascular diseases, 23(3), e221-e227.
Department of medical services. Thailand Medical Services Profile 2011-2014. Nonthaburi: Ministry of public health; 2014.
Kuriakose D, Xiao ZJIjoms. Pathophysiology and treatment of stroke: present status and future perspectives. 2020;21(20):7609.
Health Data Center. Stroke and Hypertension. 2021. Available at: https://hdcservice.moph.go.th/hdc/ reports/page.php?cat_id=6a1fdf282fd28180eed- 7d1cfe0155e11. Accessed on 23 June 2021.
Lemeshow S, Hosmer DW, Klar J, Lwanga SK, World Health Organization. Adequacy of sample size in health studies. Chichester: Wiley; 1990.
Hanchaiphiboolkul S, Poungvarin N, Nidhinandana S, Suwanwela NC, Puthkhao P, Towanabut S, Tantirittisak T, Suwantamee J, Samsen M. Prevalence of stroke and stroke risk factors in Thailand: Thai Epidemiologic Stroke (TES) Study. Journal of the Medical Association of Thailand. 2011;94(4):427-436.
O’Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. The Lancet. 2010;376(9735):112-23.
Sarfo FS, Mobula LM, Sarfo-Kantanka O, Adamu S, Plange-Rhule J, Ansong D, et al. Estimated glomerular filtration rate predicts incident stroke among Ghanaians with diabetes and hypertension. Journal of the Neurological Sciences. 2019;396:140-7.