The amount of isoflavones in soybeans and breast cancer: A systematic review and meta-analysis
Main Article Content
Abstract
Background: Breast cancer is a serious disease among women and that the major cause of death among women who had this disease in the world. Many articles suggest more consume soy, which has isoflavone, could prevent breast cancer. However, the amount of isoflavone for preventing of breast cancer remains in discussion. Hence, the researchers are interested in studying the amount of isoflavones in soybeans that could prevent breast cancer among women.
Method: The systematic review and meta-analysis were based on papers published from 2010 to 2019 through PubMed, Science Direct, Web Of Science, World Health Organization (WHO), International Agency For Research On Cancer (IARC), Center For Disease Control And Prevention, Cellular And Molecular Biomechanism Laboratory, United States Department Of Agriculture, and National cancer institute. We included 8 papers that met the inclusion criteria and then data was analyzed.
Result: The consumption of isoflavones among Asians is around 25.42 mg/d could reduce the risk of breast cancer, while, approximately 5.79 mg/d. would suggest for Europeans.
Conclusion: The amount of isoflavones to prevent breast cancer for Asians is 25.42 mg/d and for Europeans is 5.79 mg/d
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
International Agency for Research on Cancer. Global Cancer Observatory: Cancer Today [Internet]. 2020 [cited 2022 October 26]. Available from: https://gco.iarc.fr/today/data/factsheets/ cancers/39-All-cancers-fact-sheet.pdf
National Cancer Institute. Hospital Based Cancer Registry Annual Report 2020. [Internet]. 2021 [cited 2022 October 26]. Available from https://www. nci.go.th/e_book/hosbased_2563/index.html
National Cancer Institute. Hospital Based Cancer Registry Annual Report 2019. [Internet]. 2020 [cited 2022 October 26]. Available from https://www.nci.go.th/th/File_download/Nci%20Cancer%20 Registry/Hospital- Based%202019%20NCI.pdf
National Cancer Institute. Hospital Based Cancer Registry Annual Report 2018. [Internet]. 2019 [cited 2022 October 26]. Available from https://www.nci.go.th/th/File_download/Nci%20Cancer%20 Registry/Hospital%20Based_2018.pdf
National Cancer Institute. Hospital Based Cancer Registry Annual Report 2017. [Internet]. 2018 [cited 2022 October 26]. Available from https://www.nci.go.th/th/File_download/Nci%20Cancer%20 Registry/HOSPITAL-BASED%202016%20Revise%20 4%20Final.pdf
National Cancer Institute. Hospital Based Cancer Registry Annual Report 2016. [Internet]. 2017 [cited 2022 October 26]. Available from https://www.nci.go.th/th/File_download/Nci%20Cancer%20 Registry/Hospital-Based%20NCI2%202016%20 Web.pdf
Messina M. Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients. Forschende Komplementarmedizin (2006). 2016;23(2):75-80
Mourouti N, Panagiotakos DB. Soy food consumption and breast cancer. Maturitas. 2013;76(2):118-22.
Wada K, Nakamura K, Tamai Y, Tsuji M, Kawachi T, Hori A, et al. Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study. International journal of cancer. 2013;133(4):952-60.
Maskarinec G, Ju D, Morimoto Y, Franke AA, Stanczyk FZ. Soy Food Intake and Biomarkers of reast Cancer Risk: Possible Difference in Asian Women? Nutrition and cancer. 2017;69(1):146-53.
Charin Thawornkuno. Soy isoflavones: Biochemistry, mechanism of action and implication for breast cancer preventions. Thai J. Genet. 2014;7(1):7–15
Nechuta SJ, Caan BJ, Chen WY, Lu W, Chen Z, Kwan ML, et al. Soy food intake after diagnosis of breast cancer and survival: an in-depth analysis of combined evidence from cohort studies of US and Chinese women. The American journal of clinical nutrition. 2012;96(1):123-32.
Zhang FF, Haslam DE, Terry MB, Knight JA, Andrulis IL, Daly MB, et al. Dietary isoflavone intake and all-cause mortality in breast cancer survivors: The Breast Cancer Family Registry. Cancer. 2017;123(11):2070-9.
Conroy SM, Maskarinec G, Park SY, Wilkens LR, Henderson BE, Kolonel LN. The Effects of Soy Consumption before Diagnosis on Breast Cancer Survival: The Multiethnic Cohort Study. Nutrition and Cancer-an International Journal. 2013; 65(4):527-37.
Chang YJ, Hou YC, Chen LJ, Wu JH, Wu CC, Chang YJ, et al. Is vegetarian diet associated with a lower risk of breast cancer in Taiwanese women? BMC public health. 2017;17(1):800.
Li L, Zhang M, Holman CDJ. Population Versus Hospital Controls in the Assessment of Dietary Intake of Isoflavone for Case-Control Studies on Cancers in China. Nutrition and Cancer-an International Journal. 2013;65(3):390-7.
Varinska L, Gal P, Mojzisova G, Mirossay L, Mojzis J. Soy and breast cancer: focus on angiogenesis. International journal of molecular sciences. 2015;16(5):11728-49.
Valachovicova T, Slivova V, Bergman H, Shuherk J, Sliva D. Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NFkappaB/ AP-1-dependent and -independent pathways. International journal of oncology. 2004;25(5):1389-95.