THE USE OF REPETITIVE TRANSCRANIAL MAGNATIC STIMULATION FOR NEGATIVE SYMPTOMS IN SCHIZOPHRENIA
Keywords:
repetitive transcranial magnetic stimulation, schizophrenia, negative symptomsAbstract
Objective: To review the literature using repetitive transcranial magnetic stimulation (rTMS) on negative
symptoms in schizophrenia.
Material and Methods: Literature review for this article was conducted via PubMed, google, Web of
Science and other medical online-databases articles and textbooks including public articles both Thai
and English language using. The search was carried out using the terms rTMS, repetitive transcranial
magnetic stimulation, negative symptoms and schizophrenia.
Results: Eleven studies based on rTMS for negative symptoms in schizophrenia (eight experimental
studies, two meta-analysis, and one review article) met eligibility criteria. These findings indicated that
active rTMS was considered an effective, safe and well-tolerated treatment option. High-frequency of 10
Hz setting applied over the left dorsolateral prefrontal cortex (DLPFC), at least 3 consecutive weeks of
treatment and using 8 years as a cutoff for duration of illness were found to be better than sham rTMS in
alleviating negative symptoms of schizophrenia.
Conclusion: rTMS was considered another useful and safe treatment which was able to improve negative
symptoms of schizophrenia. This review article suggested the need for future studies with larger sample
sizes and other factors affecting treatment.
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