RELATIONSHIP BETWEEN DURATION OF UNTREATED PSYCHOSIS AND TREATMENT OUTCOMES IN PATIENTS WITH SCHIZOPHRENIA
Keywords:
duration of untreated psychosis, schizophreniaAbstract
Objective: Study performed to assess the relationship between duration of untreated psychosis (DUP) and treatment outcomes by evaluating number and duration of re-hospitalizations along with dosage of antipsychotic drugs in patients with schizophrenia at Somdet Chaopraya institute of psychiatry that continuously followed up for 3 years.
Material and Method: This retrospective cohort study obtained data from clinical records of patients with schizophrenia diagnosed in first hospital admission at Somdet Chaopraya institute of psychiatry in 2009, 2010 and 2011 who continuously followed up for 3 years in total number of 62 cases. Afterwards, the comparison of treatment outcomes between patients with short (≤ 6 months) and long (> 6 months) DUP was performed. Percentage, mean, SD and Fisher’s exact test were used as statistical analysis.
Results: Of all 62 samples, 45 cases had long DUP and 17 patients were in the group of short one. Mean duration of untreated psychosis was 38.96 ± 50.24 months. For treatment outcomes, DUP correlated significantly with number and duration of re-hospitalizations. 91.2 % of the long DUP group had no re-hospitalization, 41.2% of the short DUP group had no re-hospitalization and 91.1% of the long DUP group of duration of re-hospitalizations that not exceeded than 20 days and 64.7% for the short DUP group.
Conclusion: DUP had significant correlation with number and duration of re-hospitalizations. Our results which found that samples in long DUP group had more favorable treatment outcomes may need further researches because of their difference from previous studies.
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