Correlation between Sushi, Von Willebrand Factor Type A, EGF and Pentraxin Domain Containing 1 (SVEP1) expression and clinical manifestation in Breast Cancer by Immunohistochemistry Method
Keywords:
SVEP1, Breast cancer, Age, Immunohistochemistry, Sushi, Von Willebrand Factor Type A, and Pentraxin Domain Containing 1 Protein, EGFAbstract
Sushi, Von Willebrand Factor Type A, EGF and Pentraxin Domain Containing 1 (SVEP1) Protein is classified as a cell adhesion molecule (CAM), which plays a key role in mediating interactions between cells. Elevated SVEP1 mRNA expression has been reported in breast cancer tissues, suggesting its potential as a prognostic marker. However, its expression at the protein level has not been extensively studied. This study aimed to evaluate SVEP1 protein expression in normal breast tissue and breast cancer tissues, with and without axillary lymph node metastasis, using immunohistochemistry. A total of 72 tissue samples were analyzed, including 21 normal breast tissues and 51 breast cancer tissues (28 with lymph node metastasis and 23 without). SVEP1 protein expression was detected in 100% (n = 51) of breast cancer tissues. Statistical analysis revealed a significant correlation between SVEP1 expression and patient age (p < 0.05), while no significant association was found with lymph node metastasis. These findings suggest that increased SVEP1 protein expression in breast cancer may be age-related, though not directly linked to metastatic status.
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