Prevalence of High-risk Human Papillomavirus Infection and Relationship with Cytological Results, among Women in Kalasin Province
Keywords:
Prevalence of HPV infection, Cervical cancer, High-risk HPVAbstract
This study investigated the prevalence of high-risk HPV infection and evaluated the relationship between the HPV non 16, 18 infections, and cytological results among 45,019 women who participated in the cervical cancer screening program in Kalasin province during 2020-2023 using HPV DNA test covering all 14 genotypes. For those infected with HPV non-16, 18, liquid-based cytology (LBC) was used for further investigation. The results showed that HPV prevalence in this study was 5.27%. The top three prevalent HPV types were HPV 16 (1.04%), HPV 52 (0.90%), and HPV 58 (0.63%), respectively. Most participants (83.46%) had single infections and the others (16.54%) had multiple infections. The age group of 30-34 years had the highest infection prevalence at 11.36% and the prevalence decreased when age increased. From cellular cytology’s results in HPV non 16, 18 infections, cell abnormalities were found higher in multiple infections (33.14%) than those in single infection (26.20%). The genotypes with the highest abnormal cells were HPV 33 (35.56%), HPV 51 (34.52%), and HPV 56 (33.96%), respectively. The age group with the highest abnormal cells was 45-49 years (32.34%). HPV prevalence study and its relationship with cytological results in each region is crucial as it can be used for cervical cancer screening and early treatment plan. Moreover, this data can be used for appropriate vaccine usage and development in specific areas.
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