Study of Renal Function Test and Lipid Profile Levels in a Cohort of HIV Patients in Thailand

Abstract

People infected with HIV/AIDS who are regularly receiving antiretroviral therapy tend to live longer and might lead to an increase of age-associated comorbidities that can relate to the risk of non-communicable diseases (NCDs). The aim of this study was to determine kidney function and lipid levels in 4,790 HIV-infected people receiving antiretroviral therapy. The kidney function, lipid levels were compared between 2 groups who were < 50 years old and ≥ 50 years old. The results showed that the elderly group (≥ 50 years) has creatinine level significantly higher than that in the younger age group (mean (SD) =1.00 (0.95) and 0.85 (0.34) mg/dL, respectively) (p < 0.0001) and lower eGFR level in the elderly compared to that in the younger group (44.8% and 78.5%, respectively) (p< 0.001). The elderly group with eGFR < 60 mL/min/1.73 m² was more at risk of CKD (stage3-5) than the younger group (12.7% and 2.0 %, respectively).  The mean (SD) of cholesterol (n=4,428) and triglycerides (n=4,653) in the elderly group were higher than those in the younger group: 206.3 (42.3) and 200.1 (41.1) mg/dL., 181.9 (119.5) and 166 (138.7) mg/dL, respectively (p< 0.0001, < 0.001, respectively). HDL and LDL levels were not significantly different between the two groups (52.3 (16.7), 52.2 (16.4) and 127 (35.1), 129.0 (34.4) mg/dL) (p=0.88 and p=0.28, respectively). Therefore, laboratory monitoring should be carried out closely for better life quality and appropriate care of HIV infected individuals.