Association between XPD  Codon 312 Polymorphisms  and breast Cancer Risk in Thai women

Authors

ธีรกุล อาภรณ์สุวรรณ ภาควิชาเทคนิคการแพทย์ คณะสหเวชศาสตร์ มหาวิทยาลัยธรรมศาสตร์ จังหวัดปทุมธานี

Breast cancer, Nucleotide excision repair, XPD gene, Single nucleotide polymorphisms, Real-time polymerase chain reaction

Breast cancer is the most common cancer in Thai women. Polymorphic variants of XPD

gene, which involve DNA repair systems, were found to be associated with several cancers.

The aim of this study was to investigate the association between XPD codon 312 polymorphisms

and breast cancer susceptibility in Thai women. In this study, DNA was isolated from the

peripheral blood sample of 100 patients with breast cancer and 100 healthy controls for

determinination of XPD codon 312 polymorphisms by real-time polymerase chain reaction

(RT-PCR). The results show that no significant associations were found between breast cancer

risk and XPD codon 312 polymorphisms (crude OR: 1.31, 95% CI: 0.64-2.71; p = 0.462).

Variable parameters comprising age and menopause status did not alter the findings (adjusted

OR: 1.14, 95% CI: 0.66-1.98; p = 0.635) suggesting that XPD codon 312 polymorphisms is not

associated with breast cancer risk.