Efficacy of sublingual misoprostol for management of early pregnancy failure


  • Sarinya Thongpoonphan Department of Obstetrics and Gynecology, Warinchamrab Hospital, Ubon Ratchathani


Misoprostol, Sublingual, Early pregnancy failure


The purpose of this research was to evaluate the effectiveness, side effects, and complications of medical treatment with sublingual misoprostol in the termination of early pregnancy failure. A retrospective descriptive study was performed in the 50th Anniversary Mahavajiralongkorn Hospital Ubonratchatani from January 1st, 2019 to February 28th, 2021. There were 53 in-patient pregnant women reviewed with ultrasonographically diagnosed anembryonic pregnancy or intrauterine embryonic death during the first trimester. A 400 microgram of misoprostol was administered sublingually. The treatment was repeated at intervals of 4 hours (no more than 3 times within 24 hours). The main outcome included a success rate of termination, mean induction–to-abortion time, the total dose of misoprostol, and side effects were analyzed. The result showed that the success rate of complete abortion within 48 hours was 71.7%. The mean induction-to-abortion time was 13.49±7.25 hours. The two most common side effects were fever and diarrhea at 83.0% and 30.2%, respectively. There were no serious complications reports. In conclusion, the sublingual route of administration of misoprostol appeared to be safe and effective for the management of early pregnancy failure.


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How to Cite

Thongpoonphan, S. (2022). Efficacy of sublingual misoprostol for management of early pregnancy failure. Journal of Medicine and Public Health, Ubon Ratchathani University, 5(3), 202–209. Retrieved from https://he01.tci-thaijo.org/index.php/jmpubu/article/view/256683



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