Weight and height changes in patients aged 6 - 18 years with attention-deficit/hyperactivity disorder treated with methylphenidate at Siriraj hospital
Keywords:
attention deficit hyperactivity disorder, body height, body weight, growth, methylphenidateAbstract
Objective: To study the growth of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) treated with short-acting methylphenidate for up to 10 years.
Methods: Newly diagnosed ADHD patients from 2010 - 2011 aged 6 - 18 years who received short-acting methylphenidate for at least 6 months at Siriraj Hospital were included in this retrospective study. Weight and height at baseline and 6 months, 1 year, 2 years, 3 years, 4 years, 6 years, 8 years, and 10 years after receiving the medication were collected and converted to weight for age, height for age, weight for height, and z-scores. The paired t-test was used to compare the z-scores of the height and weight at different time points.
Results: A total of 94 participants were recruited, with 79% being male and mean age at diagnosis of 8 years and 5 months. The average daily dose of short-acting methylphenidate was 22.60 ± 7.92 mg/day. The weight z-scores significantly decreased compared to baseline during the first 3 years after the initiation of the medication. The height z-scores significantly decreased during the first half year. After that, the changes in height z-scores were not consistently statistically significant.
Conclusion: The weight and height changes of children and adolescents with ADHD who were treated with short-acting methylphenidate were affected only for a short period of time.
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