Pharmaceutical therapy-related quality of life in Thai depressive outpatients
Keywords:
antidepressant, depression, quality of lifeAbstract
Objectives: To evaluate pharmaceutical therapy-related quality of life in depressive outpatients and to assess its relationships with patients’ demographic and clinical characteristics.
Methods: One hundred and thirty-eight outpatients with depression were purposively selected at Srithanya hospital between April 2018 and March 2019. Health-related quality of life with respect to medication therapy was assessed using the patient-reported outcomes measure of pharmaceutical therapy (PROMPT). The PROMPT consists of 16 items and eight domains: medicine and disease information, satisfaction of medicine effectiveness, impacts of medicines and side effects, psychological impacts of medication use, convenience, availability and accessibility, therapeutic relationships with healthcare providers, and overall quality of life. Multivariate linear regressions were used to assess the relationships between eight PROMPT domain scores and patient’s demographic and clinical characteristics.
Results: Mean scores of eight PROMPT domains ranged between 58 and 80 (moderate-to-excellent level of pharmaceutical therapy-related quality of life). The domains with the lowest and highest scores were medication and disease information and availability/accessibility, respectively. Young age, female, lower education, having financial burden, more number of medications, having side effects of medication, and perceived poor disease control were significantly correlated with lower PROMPT domain scores.
Conclusion: Healthcare providers should provide adequate drug and disease information to patients and pay more attention to correlates of pharmaceutical therapy-related quality of life, including financial burden, the number of medications per day, side effects of medication and perceived level of disease control.
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