Factors associated with successful treatment outcomes in Pulmonary tuberculosis among older people in Bangkok

Main Article Content

Paphassara Borngern
Chonlawat Chaichan
Wachiraporn Wanichnopparat
Krit Prasittichok
Preecha Prempree
Chalo Sansilapin

Abstract

The incidence and mortality rates of pulmonary tuberculosis (TB) have been steadily increasing among the older population. This study aimed to identify factors associated with treatment success in older people with pulmonary TB in the Bangkok metropolitan area. A nested case-control study design was employed, with a 1:1 ratio, using retrospective data from the National Tuberculosis Information Program (NTIP) database. The study population consisted of 245 successfully treated patients (cases) and 245 treatment failure patients (controls). Conditional logistic regression analysis was conducted to determine factors associated with treatment success. The results showed that two factors were significantly associated with treatment success in older people with pulmonary TB in Bangkok. The absence of comorbidities, specifically diabetes mellitus, was found to be significantly associated with treatment success (Adjusted Odds Ratio [AOR]: 11.36, 95% Confidence Interval [CI]: 4.64- 27.80). Additionally, patients with negative acid-fast bacilli (AFB) smear results during the second month of treatment had a higher likelihood of treatment success (AOR: 13.73, 95% CI: 4.02-46.94). Based on these findings, it is recommended to implement policies and strategies for screening and closely monitoring older people with pulmonary TB, particularly those with comorbidities such as diabetes mellitus, and patients with positive AFB smear results during the intensive phase of treatment. This approach aims to enhance access to effective treatment and ensure close follow-up, ultimately improving treatment success rates for pulmonary TB in the older population.

Article Details

How to Cite
1.
Borngern P, Chaichan C, Wanichnopparat W, Prasittichok K, Prempree P, Sansilapin C. Factors associated with successful treatment outcomes in Pulmonary tuberculosis among older people in Bangkok. IUDCJ [Internet]. 2023 Dec. 19 [cited 2024 May 29];8(2):1-20. Available from: https://he01.tci-thaijo.org/index.php/iudcJ/article/view/263986
Section
Research Articles

References

Organization W. Global Tuberculosis Report 2022 [Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022.

DivisionofTuberculosis. Guide to learn, understand to tuberculosis for village health volunteers Department of Disease Control: Bureau of Tuberculosis; 2013 [Available from: https://sites.google.com/site/tbknowledge/tb-media/print/tb-knowledge-for-health-volunteer.

Johnson C, Moore Ka Fau - Patterson-Johnson, J., & Patterson-Johnson, J., 2017. (2017). Tuberculosis: Still an emerging threat. 2017(1538-8662 (Electronic)).

Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology. 2007;120(4):435-46.

Latkin C, Mandell W Fau - Oziemkowska M, Oziemkowska M Fau - Celentano D, Celentano D Fau - Vlahov D, Vlahov D Fau - Ensminger M, Ensminger M Fau - Knowlton A, et al. Using social network analysis to study patterns of drug use among urban drug users at high risk for HIV/AIDS. (0376-8716 (Print)).

กรมกิจการผู้สูงอายุ. สถิติผู้สูงอายุไทย ปี พ.ศ. 2565: กระทรวงการพัฒนาสังคมและความมั่นคงของมนุษย์; [Available from: https://www.dop.go.th/th/know/side/1/1/1159.

NTIPreport. NTIP individual report Data Center 2565 [Available from: https://ntip-ddc.moph.go.th/uiform/MainFeedSummary.aspx.

NTPThai. National tuberculosis control programme guideline, Thailand 2021. Bangkok: Division of Tuberculosis; 2021. Report No.: 978-616-11-4749-5.

Chaves Torres NM, Quijano Rodríguez JJ, Porras Andrade PS, Arriaga MB, Netto EM. Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis. PLoS One. 2019;14(12):e0226507.

Chidambaram V, Tun NL, Majella MG, Ruelas Castillo J, Ayeh SK, Kumar A, et al. Male Sex Is Associated With Worse Microbiological and Clinical Outcomes Following Tuberculosis Treatment: A Retrospective Cohort Study, a Systematic Review of the Literature, and Meta-analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021;73(9):1580-8.

Yoon YS, Jung JW, Jeon EJ, Seo H, Ryu YJ, Yim JJ, et al. The effect of diabetes control status on treatment response in pulmonary tuberculosis: a prospective study. Thorax. 2017;72(3):263-70.

Anunnatsiri S, Chetchotisakd P, Wanke C. Factors associated with treatment outcomes in pulmonary tuberculosis in northeastern Thailand. Southeast Asian J Trop Med Public Health. 2005;36(2):324-30.

Tunteerapat P, Sanwacharasontone N, Apisuk S, Sanmane U. Treatment Success Rate and Factors Associated with Treatment Success in Tuberculosis Patients in Bamrasnaradura Infectious Diseases Institute. Journal of Bamrasnaradura Infectious Diseases Institute (Thai). 2021;15(1):14-24.

Phochanasomboon K. Outcomes of Pharmaceutical Care in Tuberculosis Patients at Faculty of Medicine Vajira Hospital, Navamindrahiraj University. Vajira Medical Journal : Journal of Urban Medicine. 2016;60(3):171-80.

รุ่งอร่ามศิลป์ ศ. ปัจจัยที่มีผลต่อระยะเวลารักษาวัณโรคในโรงพยาบาลบุรีรัมย์. วารสารการแพทย์โรงพยาบาลศรีสะเกษ สุรินทร์ บุรีรัมย์. 2018;24(2):49-58.

Chang CT, Esterman A. Diagnostic delay among pulmonary tuberculosis patients in Sarawak, Malaysia: a cross-sectional study. (1445-6354 (Electronic)).