Factors Related to Rational use of oral NSAIDs for Musculoskeletal Disorder Patients in Bangphae Hospital, Ratchaburi

Abstract

         Abstracts

          The purpose of this retrospective descriptive research to examine the rational use of non-steroidal anti-inflammatory drugs (NSAIDs) and to examine appropriateness and the factors related to the rational non-steroidal anti-inflammatory drugs (NSAIDs) useed in patients with musculoskeletal disorders. The 3,438 participants were selected from medical records of patient services in Bangphae Hospital between 2016-2018. The instrument used were data record form from medical records that included personal data, drug information, the risk of cardiovascular disease assessment, the risk of gastrointestinal bleeding complications, and the rational of oral NSAIDs use. The results were as follows: The majority of the participants were females (67.7%), had underlying disease/co-morbidity (71.0%), had estimated glomerular filtration rate (eGFR) ³60 86.82%, not at high risk of developing cardiovascular disease (89.10%), and high risk of gastrointestinal bleeding complications (53.87%). In terms of rational drug use, NSAIDs were not used in patients with a history of drug allergy (100%), and with glomerular filtration rate < 60% (86.82%). Moreover, Diclofenac was not used in patients at high risk of developing cardiovascular disease (81.12%). NSAIDs were used in patients with a high risk of gastrointestinal bleeding complications with 70.80% of preventive medication. Most patients were not reported to receive duplicate NSAIDs medication (99.56%). Factors related to rational NSAIDs use were congenital diseases (p<.05), age , eGFR, risk of cardiovascular disease and risk of  gastrointestinal  bleeding  complication  (p<.001). Sex and other-drugs used were not associated with rational NSAIDs use.

Keywords: Rational drug use, Non-steroidal anti-inflammatory drug, NSAIDs, Musculoskeletal disorders