Clinical Care Guideline for the Newborn with Persistent Pulmonary Hypertension of the Newborn with Meconium Aspiration Syndrome: A Scoping review

Authors

  • Susheewa Wichaikull Boromarajonnani College of Nursing Nopparat Vajira, Faculty of Nursing, Phraborommarajchanok Institute
  • Thassanee Jaipugdee Nopparat Rajathanee Hospital

Keywords:

PPHN, MAS, Newborn, CNPG, CNP

Abstract

Introduction: Persistent pulmonary hypertension of the newborn (PPHN) is a critical condition resulting in severe oxygen deprivation, metabolic acidosis, and respiratory distress which lead to motility rate.

Research objectives: To review the scope of research on existing clinical practice guidelines to identify comprehensive recommendations for the care of newborns with PPHN and meconium aspiration syndrome (MAS).

Research methodology: This scoping review method was applied. The literatures published less than 10 years related to keywords including factors, treatment, and nursing care of newborns with MAS and PPHN based on inclusion criteria were systematically reviewed and selected by using critical appraisal tool from The Joanna Briggs Institute. All literatures were met international standard and used worldwide.

Results: Sixty - four studies were selected based on inclusion criteria and critical appraisal tool. There were 13 studies related to risk factors, 4 studies related to treatment, 12 studies were related to nursing care and the standards of PPHN with MAS and 2 studies related to the standards of PPHN

Conclusion: MAS was the highest risk to PPHN.  Standard treatment for PPHN focused on vasodilation, respiratory failure prevention and other complications such as sepsis, hypotension.
The clinical care guideline for PPHN with MAS aimed to 1) assess postpartum dyspnea 2) prevent respiratory failure; 3) prevent cardiovascular failure; 4) prevent hospital acquired infection; 5) prevent fluid, nutrient, and electrolyte imbalances; 6) prevent hypothermia, especially in low birth weight or premature infants; 7) decrease stress and pain from procedures, and 8) promote growth and reduce stress for the family.

Implication: Standards of nursing care should be developed for newborns with persistent pulmonary hypertension due to meconium aspiration syndrome.

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References

Nandula PS, Shah SD. Persistent pulmonary hypertension of the newborn. In: StatPearls [Internet]. 2023 [cited 2023 Jul 31] Available from: https://www.ncbi.nlm.nih.gov/books/NBK430685/

Kaveh M, et al. A prospective study of neonates with persistent pulmonary hypertension of the newborn: prevalence, clinical outcomes, and risk factors. Iranian Journal of Neonatology 2022;13(2):112-9.

Manunya A. Persistent pulmonary hypertension of the newborn at Somdejphrajaotaksinmaharaj hospital. Region 3 Medical and Public Health Journal 2022;9(3):196-211. Available from: https://he02.tci-thaijo.org/index.php/udhhosmj/article/view/250818/170540 (in Thai)

Apiwattanaporn M. Persistent pulmonary hypertension of the newborn in Udonthani hospital. Udonthani Hospital Medical Journal 2021;29(1):30-37. (in Thai)

Chaiteerakij P. Persistent pulmonary hypertension of the newborn at Kratumbaen hospital Samut Sakhon province. Reginal 4-5 Medical Journal 2020;39(3):304-15. Available from: https://he02.tci-thaijo.org/index.php/reg45/article/view/246176/167361 (in Thai)

Punahitanon S. Persistent pulmonary hypertension of newborn. In: Punahitanon, Santi, editor. in Smart Practice in Neonatal Care. Bangkok: Active Print Company; 2021. (in Thai)

Singh Y. and Lakshminrusimha, S. Pathophysiology and management of persistent pulmonary hypertension of the newborn. Clinical Perinatal 2021;48(3):595–618. doi: 10.1016/j.clp.2021.05.009

Zhou R, Zheng Y, Zhang X, Cheng Y. Meta-analysis of the risk factors of persistent pulmonary hypertension in newborns. Frontiers in Pediatrics 2021;9(10):1-6. doi: 10.3389/fped.2021.659137

Liu X., Mei M. Chen, X. et al. . Identification of genetic factors underlying persistent pulmonary hypertension of newborns in a cohort of Chinese neonates. Respiratory Research 2019;174(20):2-10. doi: 10.1186/s12931-019-1148-1

Ball MK, Seabrook RB, Bonachea EM, et al. Evidence-Based Guidelines for acute stabilization and management of neonates with persistent pulmonary hypertension of the newborn. American Journal of Perinatology 2023;40(14):1495-1508. doi:10.1055/a-1711-0778

Rosenzweig EB, Abman SH, Adatia I, et al. Paediatric pulmonary arterial hypertension: updates on definition, classification, diagnostics and management. European Respiratory Journal 2019;53(3):1-18. doi: 10.1183/13993003.01916-2018

Singh P, Deshpande S, Nagpa R, Caregrat R, Gupta S, Suryawanshi P. Management of neonatal pulmonary hypertension-a survey of neonatal intensive care units in India. BioMed Central Pediatrics 2023;23(149):1-9. doi: 10.1186/s12887-023-03964-9

Martinho S, Adão R, Leite-Moreira AF, Brás-Silva L. Persistent pulmonary hypertension of the newborn: pathophysiological mechanisms and novel therapeutic approaches. Frontiers in Pediatrics [Internet]. 2020 [cited 2020 July 24] Available from: https://www.frontiersin.org/articles/10.3389/fped.2020.00342/ful

Hengrasmee K. Thai guideline for diagnosis and treatment of pulmonary hypertension. The Heart Association of Thailand [Internet]. 2013 [cited 2013 Dec 8] Available from: http://www.thaiheart.org/images/column_1385016166/PAH_guideline_2013.pdf

Satalalai N, Wichaikull S. The establishment of nursing standard of prevention and caring for persistent pulmonary hypertension of newborn, Nopparat Rajathanee hospital. Journal of The Department of Medical Services 2017;42(2):76-85. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/248891 (in Thai)

Peters MDJ, Godfrey C, McInerney P, Munn Z, Tricco AC, Khalil, H. Chapter 11: Scoping Reviews (2020 version). Aromataris E, Munn Z, editors. JBI Manual for evidence synthesis. JBI [internet]. 2020 [cited 2020 Nov 8] Available from: https://doi.org/10.46658/JBIMES-20-01

Cheerapun N. Nursing care in neonates diagnosed with persistent pulmonary hypertension of the newborn using inhaled nitric oxide: case study. Mahasarakham Hospital Journal 2022;17(3):100-11. Available from: https://he02.tci-thaijo.org/index.php/MKHJ/article/view/242018/169587 (in Thai)

Jintrawet U, Klunklin P, Sripusanapan A. Nursing care in children with pulmonary hypertension. Nursing Journal 2020;47(3):460-8. Available from: https://he02.tci-thaijo.org/index.php/cmunursing/article/view/245779 (in Thai)

Pantian L. The development of evidence based practice for ventilator associated pneumonia prevention. Thammasat University Hospital Journal 2022;5(3):45-54. Available from: https://he02.tci-thaijo.org/index.php/TUHJ/article/view/247713 (in Thai)

Phanthawasit M. Nursing care for the premature infants: case series 2 cases. Mahasarakham Hospital Journal 2015;12(2):113-20. Available from: https://he02.tci-thaijo.org/index.php/MKHJ/article/view/253023/171858 (in Thai)

Pongsopa N. Persistent pulmonary hypertension of the newborn at Suratthani hospital. Reginal 11 Medicine Journal 2018;30(1):49-59. Available from: https://he02.tci-thaijo.org/index.php/Reg11MedJ/article/view/166540 (in Thai)

Pantian L. Clinical nursing practice guideline for umbilical catheter care. Thammasat University Hospital Journal 2022;7(2): 61-4. Available from: https://golink.icu/LGF1qFn (in Thai)

Mala, Kain VJ, Forster EM. Evaluating an educational program for enhancing neonatal intensive and special care nurses’ and midwives’ competence with neonatal pain management: A quasi-experimental study. Journal of Neonatal Nursing. 2023;30(4):380-7 Available from: https://doi.org/10.1016/j.jnn.2023.11.013.

Hill NS, Preston LR, Roberts KE. Inhaled Therapies for Pulmonary Hypertension. Respiratory Care 2015;60(6):794-805. doi: https://doi.org/10.4187/respcare.03927

Chinthanawongsa P, Chittham N. Comparison of the high alert drug testing program with traditional method on medication errors in neonatal intensive care unit. Chonburi Hospital Journal 2019;44(3):199-206. Available from: https://thaidj.org/index.php/CHJ/article/view/5885/7638 (in Thai)

Chaonarin P, Deawprasert T, Ariyaprana P, Keeratavanithsathian S. Prevention of hypothermia in the newborn. Thai Journal of Nursing 2021;70(4):52-9. Available from: https://he02.tci-thaijo.org/index.php/TJN/article/view/250333 (in Thai)

Siefkes HM, Lakshminrusimha S. Management of systemic hypotension in term infants with persistent pulmonary hypertension of the newborn (PPHN) – an illustrated review. Biomedical Journal 2021;16(4):1-27. doi: 10.1136/archdischild-2020-319705

Ahmed AA, Al-Rafay SS, Mohamed F, El-Gadban F. Performance of nurses caring for neonates with persistent pulmonary hypertension. Egyptian Journal of Health Care 2022;13(3):487-97. Available from: https://ejhc.journals.ekb.eg/article_253605_e4353b376bfa28eb1b9d9c44f1e74f6d.pdf

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Published

2024-08-28

How to Cite

1.
Wichaikull S, Jaipugdee T. Clinical Care Guideline for the Newborn with Persistent Pulmonary Hypertension of the Newborn with Meconium Aspiration Syndrome: A Scoping review. JBCN_Bangkok [internet]. 2024 Aug. 28 [cited 2026 Jan. 28];40(2):213-25. available from: https://he01.tci-thaijo.org/index.php/bcnbangkok/article/view/268868

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Research articles