Relationship Between Single - Item Self - Report Medication Adherence Question and Virological failure in People Living with HIV (PLWH)
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Abstract
Antiretroviral drugs adherence is essential for treating HIV patients. Self-report is the most common method for assessing medication adherence in clinical practice, because of low cost and ease of implementation. This study aimed to investigate the association of single-item self-report medication adherence question of antiretroviral medication and virological failure in people living with HIV (PLWH). Matched case-control study design was used. Data were retrieved from HIV database. Conditional logistic regression was used for data analysis. One hundred twenty-two HIV patients, who are older than 18 years old, were divided by matching in 1:1 ratio by sex and antiretroviral regimens into two groups: patients with virological failure and patients with non-virological failure. Good medication adherence was 35.94% and 64.06% of patients with virological failure and non-virological failure, respectively. The analytic results showed that, after adjusting for gender, age, antiretroviral regimens, opportunistic diseases and CD4 cell count level, patients with poor medication adherence have higher probability to develop virological failure compared to the good medication adherence (OR=10.03; 95%Cl=2.325-43.258; p-value=0.002). Single-item self-report medication adherence question of antiretroviral medication may be served as a simple alternative for assessing adherence and predicting virological efficacy among HIV patients in situation with limited time to care for patients.
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References
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