Coronavirus Disease-19 (COVID-19)
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Abstract
In December 2019, World Health Organization (WHO) was informed of patients with unknown cause of pneumonia reported in Wuhan, Hubei province of the People’s Republic of China. A novel coronavirus, SARS-CoV-2 was subsequently identified as the causative pathogen and the outbreak has spread to other countries. The genome of SARS-CoV-2 outbreak which causes coronavirus disease 19 (COVID-19) shared about 80% nucleotide sequence identity to human SARS-CoV that previously reported. SARS-CoV-2
can cause of pneumonia and leading to the progress of respiratory failure effect the fatality rate about 3.4 %. Elderly population with comorbidities were increased risk for more severe disease. The evidence of human-to-human transmission was confirmed. Phylogenetic study suggested that SARS-CoV-2 originated from bat but intermediate host that transmitting the virus to human is remaining unknown. Detection of SARS-CoV-2 nucleic acid by real-time polymerase chain reaction (real-time PCR) was used for COVID-19 diagnosis. Since March 17, 2020, 177 cases were confirmed with COVID-19 infection and one death case was
reported in Thailand. Currently, there is no specific antiviral drug recommended for treatment nor vaccine to prevent are available. Thus, the knowledge about COVID-19 is important for outbreak preparedness and disease control in Thailand.
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References
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