Factors Associated with Self-reported Medication Adherence in Depressive Outpatients
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Abstract
Objective: To study medication adherence in depressive outpatients, and to compare medication adherence among patients with different characteristics including education level, heath benefit, drug preparation, number of drug items, and adverse drug reactions. Methods: A cross-sectional study of 138 outpatients, treated and receiving drugs in Srithanya Hospital between May and July 2018, collected the data using the MTB-Thai (medication taking behavior measure for Thai patients) and the MA-VAS (medication adherence visual analog scale). Results: The MTB-Thai had full scores of 4 for each dimension. Average score on unintentional domain or forgetfulness in medication taking was 3.32 ± 0.75. Average score on intentional domain on drug discontinuation, self-adjustment of drug dosage or intended skipping of drugs was 3.73 ± 0.52. The MA-VAS had a full score of 100 with a mean score of 87.38 ±. 1.19. The study did not find any factors affecting the MTB-Thai score, but those who reported having adverse drug reactions had a significantly lower MA-VAS score than those who had no adverse effects. Conclusion: Adverse drug reactions had a significant impact on medication adherence scores of depressive patients.
Article Details
ผลการวิจัยและความคิดเห็นที่ปรากฏในบทความถือเป็นความคิดเห็นและอยู่ในความรับผิดชอบของผู้นิพนธ์ มิใช่ความเห็นหรือความรับผิดชอบของกองบรรณาธิการ หรือคณะเภสัชศาสตร์ มหาวิทยาลัยสงขลานครินทร์ ทั้งนี้ไม่รวมความผิดพลาดอันเกิดจากการพิมพ์ บทความที่ได้รับการเผยแพร่โดยวารสารเภสัชกรรมไทยถือเป็นสิทธิ์ของวารสารฯ
References
World Health Organization. Depression and other common mental disorders: Global health estimates [online] 2017. [cited Oct 13, 2019]. Available from: www.who.int/mental_health/management/depression/prevalence_global_health_estimates/en/
Kittirattanapaiboon P, Tantirangsee N, Chutha W, Tanaree A, Kwansanit P, Assanangkornchai S, et al. Prevalence of mental disorders and mental health problems: Thai national mental health survey 2013. Nonthaburi: Beyond Publishing; 2016.
Department of Mental Health. Report on number of patients receiving psychiatric cares in the national level in budget year 2018 [online] 2018. [cited Oct 13, 2019]. Available from: dmh.go.th/report/datacen ter/hdc/reds.asp.
Keller MB, Hirschfeld RM, Demyttenaere K, Baldwin DS. Optimizing outcomes in depression: Focus on antidepressant compliance. Int Clin Psychopharma col 2002; 17: 265-71.
Choorat N. The study of causes and ways to prevent a recurrence of schizophrenic patients in the community of Pi-leng district health care promoting hospitals which experiencing unrest situation in the southern provinces of Thailand. The Princess of Naradhiwas University Journal of Humanities and Social Sciences 2016; 3: 24-36.
Hatch A, Docherty JP, Carpenter D, et al. Expert consensus survey on medication adherence in psychiatric patients and use of a digital medicine system. J Clin Psychiatry 2017; 78: 803-12.
Lindstrom E, Lewander T, Malm U, et al. Patient-rated versus clinician-rated side effects of drug treatment in schizophrenia. Clinical validation of a self-rating version of the uku side effect rating scale (uku-sers-pat). Nord J Psychiatry. 2001; 55(Suppl 44): 5-69.
Sabate E. Adherence to long-term therapies: Evidence for action. Geneva: World Health Organization; 2003.
Cipolle RJ, Strand L, Morley P. Pharmaceutical care practice. 3rd ed. New York: McGraw-Hill; 2012.
Srimongkon P, Aslani P, Chen TF. A systematic review of measures of medication adherence in consumers with unipolar depression. Res Social Adm Pharm 2019; 15: 3-22.
Lee MS, Lee HY, Kang SG, Yang J, Ahn H, Rhee M, et al. Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders. J Affect Disord. 2010; 123: 216-21.
Sakthong P, Sonsa-Ardjit N, Sukarnjanaset P, Munpan W, Suksanga P, et al. Development and psychometric testing of the medication taking behavior tool in Thai patients. Int J Clin Pharm. 2016; 38: 438-45.
Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens 2008; 10: 348-54.
Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: L Erlbaum Associates; 1988.
Fayers PM, Machin D. Quality of life: The assess ment, analysis, and reporting of patient-reported outcomes. 3rd ed. Chichester: Wiley Blackwell; 2016.
Serna MC, Real J, Cruz I, Galván L, Martin E. Monitoring patients on chronic treatment with antidepressants between 2003 and 2011: Analysis of factors associated with compliance. BMC Public Health. 2015; 15: 1184.
Muzina DJ, Malone DA, Bhandari I, Lulic R, Baudisch R, Keene M. Rate of non-adherence prior to upward dose titration in previously stable antidepressant users. J Affect Disord 2011; 130: 46-52.
Sedlackova Z, Kamaradova D, Prasko J, Látalová K, Ocisková M, Ocisková M, et al. Treatment adherence and self-stigma in patients with depressive disorder in remission - a cross-sectional study. Neuro Endocrinol Lett 2015; 36: 171-77.
Kamaradova D, Latalova K, Prasko J, Kubinek R, Vrbova K, Mainerova B, et al. Connection between self-stigma, adherence to treatment, and discontinu- ation of medication. Patient Prefer Adherence. 2016; 10: 1289-98.
Krivoy A, Balicer RD, Feldman B, Hoshen M, Zalsman G, Weizman A, et al. The impact of age and gender on adherence to antidepressants: A 4-year population-based cohort study. Psychopharma cology (Berl). 2015; 232: 3385-90.
Lim L, Goh J, Chan YH, Poon SH. Attitudes toward utility, effects and side effects of treatment for anxiety and depression. Australas Psychiatry 2016; 24: 556-60.
Lor M, Koleck TA, Bakken S, Yoon S, Navarra AD. Association between health literacy and medication adherence among hispanics with hypertension. J Racial Ethn Health Disparities. 2019; 6: 517-24.
Briesacher BA, Andrade SE, Fouayzi H, Chan KA. Medication adherence and use of generic drug therapies. Am J Manag Care. 2009; 15: 450-6.
Bosworth HB, Voils CI, Potter GG, Steffens DC. The effects of antidepressant medication adherence as well as psychosocial and clinical factors on depression outcome among older adults. Int J Geriatr Psychiatry 2008; 23: 129-34.
Koda-Kimble MA, Alldredge BK. Applied therapeutics: The clinical use of drugs. 10th ed: Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2013.
Brunton LL, Goodman LS. Goodman and Gilman's manual of pharmacology and therapeutics. 2nd ed. New York: McGraw-Hill; 2014.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: A pathophysio logic approach. 10th ed. New York: McGraw-Hill; 2017.
Buus N, Johannessen H, Stage KB. Explanatory models of depression and treatment adherence to antidepressant medication: A qualitative interview study. Int J Nurs Stud. 2012; 49: 1220-9.
Ho SC, Jacob SA, Tangiisuran B. Barriers and facili- tators of adherence to antidepressants among outpatients with major depressive disorder: A qualitative study. Plos One. 2017; 12: e0179290.
Vannachavee U, Seeherunwong A, Yuttatri P, Chula kadabba S. The effect of a drug adherence enhancement program on the drug adherence behaviors of patients with major depressive disorder in Thailand: A randomized clinical trial. Arch Psychiatr Nurs. 2016; 30: 322-8.
