Use of Paracetamol to Minimize Pain during Second Trimester Amniocentesis: a Randomized Controlled Trial

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วรลักษณ์ เอี่ยมสำอางค์


Background: Mid-trimester amniocentesis is a routine invasive procedure that offered for the prenatal detection of genetic disease. The role of analgesia during the procedure remains unclear.
Objective: To assess the effectiveness of paracetamol to decrease pain perception during second trimester amniocentesis.
Material and method: A double-blind randomized controlled trial was conducted on pregnant women who underwent second trimester genetic amniocentesis in Lampang Hospital between October 2014 and April 2015. They were equally randomized to receive either oral paracetamol
1,000 mg or placebo 30 minutes prior to amniocentesis. Maternal anticipated and actual pain before and after amniocentesis were assessed by visual analog score. Comparison between groups were analyzed by using Fisher’s exact probability test, student t-test and rank sum test.
Results: Eighty women enrolled the study. Anticipated pain before amniocentesis was 7.2 ± 2.2 in paracetamol group and 6.8 ± 1.9 in placebo group (p=0.304). Actual pain was 3.2 ± 1.8 in paracetamol group and 3.2 ± 2.0 in placebo group (p=0.953). 
Conclusion: There was no difference between paracetamol and placebo for minimizing pain during second trimester amniocentesis.


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เอี่ยมสำอางค์ ว. (2015). Use of Paracetamol to Minimize Pain during Second Trimester Amniocentesis: a Randomized Controlled Trial. Lampang Medical Journal, 36(2), 47–53. Retrieved from
Original Article


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