Data or Evidence in Support of Topical Ya Tha Phra-Sen Traditional Medicine Formula Use in Osteoarthritis
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Abstract
“Ya Tha Phra-Sen” is the 58th Thai traditional medicine formula recorded in the King Narai’s Formulary that has been used in Thai traditional medicine since the Ayutthaya period. It was traditionally used for the relief of sen (energy) line disorders, lom am-ma-pat, pat-ta-khat, klon, cramps, chap-pong, and muscle ache. Currently, this medicinal recipe has been prepared as an external remedy for the treatment of osteoarthritis. The formula is composed of 13 herbal ingredients in descending order of proportions used, namely, Putranjiva roxburghii Wall., Senna siamea (Lam.) H.S.Irwin & Barneby, Baliospermum solanifolium (Burm.) Suresh, Cymbopogon nardus (L.) Rendle., Tamarindus indica L., Melia azedarach L., Boesenbergia rotunda (L.) Mansf., Allium sativum L., Alpinia galanga (L.) Willd., Piper nigrum L., assafoetida (Ferula assa-foetida L.), aloes (Aloe vera (L.) Burm.f.), and Allium ascalonicum L. So far, there have been research reports on biological activities, clinical studies in osteoarthritis, and product development of the formula.
This review article aimed to compile information on pharmacological activities – particularly anti-inflammatory and analgesic actions – and traditional uses of its herbal ingredients, as well as to identify research gap for further studies, by searching relevant databases, textbooks and original research articles on the traditional remedy. Results showed that the herbs contained in the Ya Tha Phra-Sen formula have medicinal properties as per the Thai traditional medicine principles, which are consistent with their pharmacological activities; and the formula can be effectively and safely used for the treatment of osteoarthritis. So, it is a good alternative treatment for osteoarthritis in medical and public health services.
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