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Andrographis paniculata (Burm. f.) Nees (fa thalai chon in Thai) is a medicinal plant that naturally grows in Muak Lek district, Saraburi province. During the flowering stage (mature plant), its andrographolide contents in various parts, from high to low, namely leaves, aerial parts, stems and flowers are 5.11%, 4.90%, 0.68% and 1.90% w/w respectively; and in the pre-flowering stage (young plant) the contents are 3.65%, 2.95% and 1.03% w/w respectively. For the treatment of COVID-19 with Andrographis herbal drug, at the andrographolide dose of 180 mg daily for 5 days, 19.6 g of fresh leaves from the young plant or 14.0 g of fresh leaves from the mature plant should be taken. As for the decoction of aerial parts of the mature plant, 2.5 240-mL glasses should be taken per day. But tea from fresh leaves, which is drunk without the pulp, has a too low andrographolide content to achieve the conventional dose for COVID-19 treatment. The results of this study are useful for the public who want to use their own fresh Andrographis herb to treat COVID-19 by themselves. The proper amount has to be calculated based on the andrographolide content in the formula they use.
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Shi TH, Huang YL, Chen CC, Pi WC, Hsu YL, Lo LC, Chen WY, Fu SL, Lin CH. Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage. Biochem Biophys Res Commun. 2020;533(3):467–73.
Sa-ngiamsuntorn K, Suksatu A, Pewkliang Y, Thongsri P, Kanjanasirirat P, Manopwisedjaroen S, Charoensutthivarakul S, Wongtrakoongate P, Pitiporn S, Chaopreecha J, Kongsomros S, Jearawuttanakul K, Wannalo W, Khemawoot P, Chutipongtanate S, Borwornpinyo S, Thitithanyanont A, Hongeng S. Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component andrographolide in human lung epithelial cells and cytotoxicity evaluation in major organ cell representatives. J Nat Prod. 2021;84(4):1261–70.
Vallop N. Department of Correction revealed that inmates already cured from COVID 94.2%. Bangkokbiznews. [Internet]. 2021 July 14; Sect. A:1 (col.1) [cited 2021 Aug 23]; Available from: https://www.bangkokbiznews.com/news/detail/948538 (in Thai)
Benjaponpithak A, Visithanon K. Sawaengtham T, Thaneerat T, Wanaratna K. Short communication on use of andrographis herb (FA THALAI CHON) for the treatment of COVID-19 patients. Journal of Thai Traditional and Alternative Medicine. 2021;19(1):229-33. (in Thai)
Swedish Herbal Institute. Effect of Kan-Jang® supplementation in patients diagnosed with COVID-19: A randomized, quadruple-blind, placebo-controlled Trial. [Internet]. [cited 2021 Aug 23]; Available from: https://clinicaltrials.gov/ct2/show/NCT04847518
Bureau of Drug and Narcotic, Department of Medical Sciences, Ministry of Public Health. Thai Herbal Pharmacopoeia 2021. [Internet]. [cited 2021 Sep 20]; Available from: https://bdn.go.th/thp//ebook/nGu4A3OCoG93qRkhoJIaqUEhnJ94LjWewEb3QWewEb3Q