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Kraduk Kai Dam (Justicia gendarussa Burm.f.) has been used in folk medicine by pounding the leaves with rice whisky and using a poultice to treat muscle pain, bruises, and joint pain. The purpose of this study was to evaluate the efficacy and safety of J. gendarussa medicated spray (JGS) in comparison with that of diclofenac spray (DFS) to treat patients with mild to moderate soft tissue injury. A randomized double-blinded controlled trial was performed in the Orthopedic Surgery Department of Chao Phya Abhaibhubejhr Hospital, Prachin Buri province, Thailand. Patients aged 15–70 years were randomly assigned to receive either two puffs of JGS or DFS thrice daily for seven days. The patients’ decreases in rest pain and swelling were considered primary outcomes, while the use of pain medication, patients’ global assessment, and reported adverse events were secondary outcomes. The results showed that there were no differences in baseline characteristics between the two groups. At the end of the study, the pain scores in the JGS and DFS groups were not different (mean difference VAS = -0.13, 95%CI -0.81, 0.56; p = 0.68); the reductions in swelling of the JGS and DFS groups were not differentt (risk ratio = 0.988, 95%CI 0.66, 1.48; p = 0.951); the amounts of paracetamol given to the patients were not different between the two groups (p = 0.194); and the skin irritation was not statistically different in both groups, i.e. 8.3% and 6.38% of the patients treated with JGS and DFS (p > 0.05), respectively. In summary, the efficacy and safety of JGS to treat mild to moderate tissue injuries were comparable to those of DFS.
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Kuehl KS. Review of the efficacy and tolerability of the diclofenac epolamine topical patch 1.3% in patients with acute pain due to soft tissue injuries. Clin Ther. 2010;32(6):1001-14.
McGriff-Lee N. Management of acute soft tissue injuries. J Pharm Prac. 2003;16(1):51-8.
Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ (Clinical research ed). 1998;316(7128):333-8.
Hu JQ, Deng YF, Daniel TF. 24. JUSTICIA Linnaeus, Sp. Pl. 1: 15. 1753. Fl. China. 2011;19:449–61. Available from: http://flora.huh.harvard.edu/china/PDF/PDF19/Justicia.pdf
Areekul S. Knowledge of wild plants used in the northern part of Thailand. Volume 2. Bangkok: Royal Project Foundation. 2009.
Ratnasooriya W, Deraniyagala S, Dehigaspitiya D. Antinociceptive activity and toxicological study of aqueous leaf extract of Justicia gendarussa Burm.f. in rats. Pharmacogn Mag. 2007;3(11):145-55.
Kavitha SK, Viji V, Kripa K, Helen A. Protective effect of Justicia gendarussa Burm.f. on carrageenan-induced inflammation. J Nat Med. 2011;65(3-4):471-9.
Saleem TK, Azeem AK, Dilip C, Sankar C, Prasanth NV, Duraisami R. Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees. Asian Pac J Trop Bio. 2011;1(2):147-9.
Paval J, Kaitheri SK, Potu BK, Govindan S, Kumar RS, Narayanan SN, Moorkoth S. Anti-arthritic potential of the plant Justicia gendarussa Burm F. Clinics (Sao Paulo, Brazil) 2009;64(4):357-62.
Liu S, Nguyen T. Ankle sprains and other soft tissue injuries. Curr Opin Rheumatol 1999;11(2):132-7.
Rodfak N, Limsakul P, Horma P, Klakaeng K, Denwong K, Samanpan S. Effectiveness of Justicia gendarussa Burm.f. and Sida rhombifolia L. medicated spray in acute and chronic pain. 2015. (unpublished research)
Massey T, Derry S, Moore RA, McQuay HJ. Topical NSAIDs for acute pain in adults. Cochrane Database Syst Rev. 2010(6):Cd007402.
Predel HG, Giannetti B, Seigfried B, Novellini R, Menke G. A randomized, double-blind, placebo-controlled multicentre study to evaluate the efficacy and safety of diclofenac 4% spray gel in the treatment of acute uncomplicated ankle sprain. J Int Med Res. 2013;41(4):1187-202.
Galer BS, Rowbotham M, Perander J, Devers A, Friedman E. Topical diclofenac patch relieves minor sports injury pain. J Pain Symptom Manage. 2000;19(4):287-94.
Derry S, Moore RA, Gaskell H, McIntyre M, Wiffen PJ. Topical NSAIDs for acute musculoskeletal pain in adults. Cochrane Database Syst Rev. 2015(6):Cd007402.