A comparison between Mathurameha and Metformin in the result of efficacy and safety among new-onset type 2 diabetes

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Sukhum Piriyapornpipat
Panee Wasanat

Abstract

This study was done to compare the efficacy and safety of Thai herbal medicine of Mathurameha and Metformine among new cases type 2 diabetes patients at Watthana Nakhon Hospital, Sa Kaeo province. The clinical research trial was conducted by prospective study and purposive sampling method. We divided new onset of diabetic type 2 cases into 2 groups. The control group was treated with Metformin (500 mg) taking 1 tablet in the morning and evening after meals (73 cases), and the experimental group was treated with Thai herbal medicine Mathurameha (300 mg), taking 2 capsules each morning and evening before meals (80 cases), for 6 months. Repeated measures ANOVA were conducted for analyze HbA1C and fasting blood sugar. Blood sampling were collected for BUN, Creatinine, Cholesterol, HDL, LDL, Triglyceride and Urine before and after the research study. Adverse event occurred throughout of the study were followed. The result found that percentage change of mean and standard deviation of fasting blood sugar (FBS) and HbA1C among new-onset diabetic patients after treatment with Mathurameha and Metformin were -1.24 ± 15.70, 8.54 ± 23.18 (FBS) and -4.67 ± 30.31, -3.90 ± 31.70 (HbA1C), respectively. No serious adverse reactions were found in both subject groups. in conclusion Mathurameha herbal medicine effective in reducing blood sugar levels. But compared to Metformin was found to be less effective. However, we found the advantages of Mathurameha were suitable for use in type 2 diabetes patients who FBS less than 220 mg/dl, relatively obese patients (BMI > 30) and age under 60 years old.

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