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Insomnia is a commonly found condition which affects the quality of life of the general population world wide. Chao Phraya Abhaibhubejhr Hospital (CAH) has incorporated a folk insomnia remedy, Kleeb Bua Daeng (KBD), which contains Nelumbo nucifera Gaertn., Centella asiatica(L.)UrbanandPiper nigrum L. into the hospital formulary since 2017. This study aimed to evaluate the effectiveness and safety of KBD insubjects with insomnia as identified by Pittsburgh Sleep Quality Index (PSQI) score of more than 5 who attended CAH’s Department of Thai Traditional and Alternative Medicine from May 1, 2017 to January 5, 2020.Fifty subjects with a mean age of 48.48 ± 14.31 years had an average PSQI score of 12.22 ± 3.12 at baseline. All participants received 2capsules of KBD (400 mg/capsule) after breakfast and before bedtime (4 capsules/day) for 4 weeks. KBD improved sleep quality with PSQI scores of 8.66 ± 3.23, 7.12 ± 3.04, 6.06 ± 2.75, and 5.30 ± 2.61 after 1, 2, 3, and 4 weeks of medications, respectively – the qualities improving significantly after the first week (p < 0.01). Regarding drug safety, there were 9 and 5 cases reporting adverse product reactions (APR) during the first three weeks and the fourth week, respectively. The adverseproduct reactions were frequent urination, giddiness/vertigo, hypotension, constipation and gastro intestinal disturbance. It has been concluded that KBD is effective and safe for improving sleep quality. However, continuous monitoring of this remedy’s efficacy should be further undertaken to see if the remedy could reduce the PSQI score to less than 5 which indicates no clinically significant insomnia.
Chaiarj S, Panya P. Insomnia and related factors. The Thai Journal of Nursing Council. 2005;20(2):1-12. (in Thai)
Schwartz S, McDowell Anderson W, ColeSR, Cornoni-Huntley J, Hays JC, Blazer D. Insomnia and heart
disease: a review of epidemiologic studies. Journal of Psychosomatic Research. 1999;47(4):313-33.
Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. Anopportunity for prevention. Journal of American Medical Association. 1989;262(11):1479-84.
Léger D, Guilleminault C, Bader G, Lévy E, Paillard M. Medicalandsocio-professional impactof insomnia.
Mortin CM, Culbert JP, Schwortz SM. Nonpharmacological interventions for insomnia: A meta analysis of treatment efficacy. American Journal of Psychiatry. 1994;151(8):1772-80.
Cheng C, WaiwutP,PlekratokeK, ChulikhitY, Daodee S , Monthakantirat O, Pitiporn S, Musigavong N,
Kwankhao P,Boonyarat C. Multi target activities of Kleeb Bua Daeng, a Thai traditional herbal formula, against
Maneenet J, Daodee S, Monthakantirat O, Boonyarat C, Khamphukdee C, Kwankhao P, Pitiporn S, Awale S, Chulikhit Y, Kijjoa A. Kleeb Bua Daeng, a Thai traditional herbal formula, ameliorated unpredictable chronic mild stress-induced cognitive impairment in ICR mice. Molecules. 2019;24(24):4587.
Rasch B, Born J. About sleep’s rolein memory.Physiological Reviews. 2013;93(2):681-766.
Jirapramukpitak T, Tanchaiswad W. Sleep disturbances among nurses of Songklanagarind Hospital. Journal of the Medical Association of Thailand.1994;42:122-31. (in Thai)
Foundation for Restoring and Promoting Thai Traditional Medicine and Ayurveda Dhamrong School, Siriraj Applied Thai Traditional Medicine, Mahidol University. The original Thai medical textbook Volume 1. (Phaetsatsongkhro Classical Thai traditional medical textbook) Volume 1Revised Version B.E. 2550 on the occasion of The Celebration son the Auspicious of His Majesty the King Bhumibol Adulyadej The Great s 80th Birthday Anniversary. Bangkok: Supawanich Publishing; 2007. (inThai)
Awad R, Arnason JT, Trudeau V, Bergeron C, Budzinski JW, Foster BC, Merali Z. Phytochemical andbiological analysis of skullcap (Scutellaria lateriflora L.): A medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):640-9.
Spielman AJ. Assessmentof insomnia. Clinical Psychology Review. 1986;6(1):11-25