Safety and Preliminary Efficacy of Thai Herbal Preparations, Luang Surat Cream (Luang Narin) and Thongnoppakhun Oil, for Treatment of Diabetic Foot and Pressure Ulcers
Article Sidebar
Main Article Content
Abstract
Diabetic foot and pressure ulcers are chronic wounds. Early intervention and proper treatment should result in complete healing without high risk complications. This study aimed to evaluate the safety and preliminary efficacy of Luang Surat (Luang narin) and Thongnoppakhun preparations in treatment of diabetic foot and pressure ulcers in 14 government hospitals in Surat Thani Province. It was found that 19 wounds from 16 patients were eligible for the study. There were no reports of adverse effects or allergic reactions throughout the period. Preliminary efficacy found that wound characteristics including texture, edge, and size of the wounds improved in almost all volunteers. It was concluded that both herbal preparations were safe and have the potential to be agents for the treatment of chronic wounds. Nevertheless, this was only the preliminary study. Further clinical studies should be performed for adequate evaluation.
Article Details
References
Absuwan N. Wolrd diabetes day. Bureau of Non Communicable Diseases. [Internet]. 2015. [cited 2019 September 10]. Available from: http://thaincd.com/document/hot%20news/ (in Thai)
Absuwan N, Panthuwej N. Wolrd Diabetes Day. Bureau of Non Communicable Diseases. [Internet]. 2014. [cited 2019 September 10]. Available from: http://thaincd.com/ document/hot%20news/ (in Thai)
Thai Traditional Medicine Research Institute, Department of Thai Traditional and Alternative Medicine. Pharmacological activities of Thai formulation: Luangnarin for the treatment of chronic ulcer (phase 1). Bangkok; 2016.
Soda N, Senavong P, Thongnoppakun S. Preliminary study of therapeutic efficiency of herbal oil remedy in chronic wound healing. Thammasat Medical Journal. 2016;16(3):438-46.
Watthanasombutti S. Pharmacovigilance. [Internet]. 2017. [cited 2019 September 10]. Available from: https://ccpe.pharmacycouncil.org/index.php? option= article_detail&subpage=article_detail&id=393 (in Thai)
Suwankesawong W, Sripirom P, Trakulpiankit P, Petcharat C, Sornsriwichai W. Evaluation of the use of Thai algorithm for adverse drug reaction monitoring. Journal of Health Science. 2016;25(4):673-82. (in Thai)
Prasangsit J. Tools to measure wound healing. Nursing Faculty, Mahidol University.
[Internet]. [cited September 2019 10]; Available from:
https://www.si.mahidol.ac.th/Th/division/nursing/NDivision/N_APN/admin/download_files/8_100_1.pdf
Hirunsirivat S, Tungsukruthai P, Tharavanij T, Sriyakul S, Chakkavittumrong P, Kongkaitpaiboon S. Safety of Yellow Surat cream in healthy participants (Clinical trial phase I). Walailak Procedia. 2019;1:IC4IR.183.
The Institute of Thai Traditional Medicine, Department of Thai Traditional and Alternative Medicine. Safety monitoring on the use of herbal medicines public hospital patients for the addition into the national list of essential medicines (2018-2019). November 2562; Department of Thai Traditional and Alternative Medicine. Nonthaburi: 2562.
Rao K, Ch B, Narasu LM, Giri A. Antibacterial activity of Alpinia galanga (L) Willd crude extract. Appl Biochem Biotech. 2010;162(3):871-84.
Gujral ML, Chowdhury NK, Saxena PN. Effect of indigenous remedies on the healing of wounds and ulcers. Jima. 1953;22(7):273-76.
Nguyen LMT, Dang VG, Le TS. Formulation and optimization of the recipe of Centella asiatica and Curcuma longa cream. Tap Chi Hoa Hoc. 2001;1:15-18.
Ajariyakul S, Sornsriwichai S, Yingpisit D. The use of Termeric in the treatment of children’s skin disease. research report (Full Paper). 2016. p. 1-62. (in Thai)
Somchaichana J, Bunaprasert T, Patumraj S. Acanthus ebrateatus Vahl. ethanol extract enhancement of the efficacy of the collagen scaffold in wound closure: A study in a full tickness-wound mouse model. J Biomed Biotechnol. 2012, Article ID 754527, 8 pages. doi:10.1155/2012/754527. (in Thai)
Samappito W, Samappito S, Buttacup L. Antibacterial activity of peel extracted from Mangosteen (Garcinia Mangostana Linn.) and Plai oil (Zingiber cassumunar Roxb.). J Sci Technol MSU. 2017;36(1):53-60.
Itharat A, Ruangnoo S, Makchuchit S, Thongdeeying P, Panthong S. Anti-inflammatory compounds of Smilax corbularia Kunth. Planta Medica, 2012;78(11). doi: 10.1055/s-0032-1320836
Itharat A. Comparative biological activities of five Thai medicinal plants called Hua-Khao-Yen. Thai J Pharmacol. 2010;32(1):327-31.
Chusri S. Wound Healing oil for Diabetic foot. [Internet]. 2018. [cited 2019 September 10]. Available from: https://www.thailandtechshow.com/upload_technology/attachment/426.pdf (in Thai)
Jenwitheesuk K. Basic wound healing and wound bed preparation. Srinagarind Med J. 2013;28(suppl):10-7. (in Thai)