Efficacy and Safety of Plook-fai-tat Formula to Increase Milk Volume in Post-partum Women with Lactation Insufficiency

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นิลเนตร วีระสมบัติ
Disdanai Amattrawong
Wilai Prakobkij
Thitiya Tunthaworn
Osaree Sawatsri
Chamaiporn Maneeratanapun
Supa Jantarawivatn
Patama Poltue
Aree Chueadet
Wasuthep Satia
Kesara Rakchantuek
Kanoknapa Narpasawad
Theeranuch Seesaard
Udsanee Sintupattanapun
Kritsanee Saramunee

Abstract

Plook-fai-tat is a Thai traditional herbal medicine formula in Mahachotirat scripture, Thai Traditional Medicine Textbook for Obstetrics and Gynecology diseases, used for augmenting breastmilk production. Plook-fai-tat has been officially included in the National List of Essential Medicines since 2012. The objective of this study was to determine efficacy, safety and patient satisfaction of Plook-fai-tat formula in increasing milk volume in postpartum mothers who have lactation insufficiency. Forty-nine subjects who had normal spontaneous vaginal delivery at term in Sung-noen and Si-kiew Hospitals voluntarily participated in the study. The participants were randomly assigned to receive Plook-fai-tat formula (3 g/day in 4 divided doses, n = 24) or placebo (n = 25). It was found that mean breastmilk volumes increased significantly in both groups within 3 days after start taking the prescribed products (p < 0.001). Mean breastmilk volumes were 51.01 ± 54.97 ml in the Plook-fai-tat formula group and 43.12 ± 40.08 ml in the placebo group: however, these increases were not statistically significant different (p = 0.567). Nevertheless, it was worth noting that in the Plook-fai-tat formula group, there were 6 persons (25%) who had an increased mean breastmilk volume of 110 ml or more, which was significantly higher than that of the placebo group which only 1 person (4%) was found (p < 0.05). No adverse reaction was detected among both groups. The result indicates that the galactogenic effect of Plook-fai-tat formula was not significantly different from that of placebo; however, the proportion of nursing mothers who had an increased breastmilk volume of 110 ml and higher in Plook-fai-tat group was significantly higher than that in the placebo group. This herbal formula is safe as no adverse drug reaction was observed.

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References

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