Main Article Content
Rational cancer are disease severity the first causes of death. Neutritional are important issue. Cancer related cachexia play a key role in the progression and outcome of neoplastic disease. Objective: Comparison the effect of Curcuma Longa L. and fish oil dietary intake on nutritional status and quality of life of cancer patients. Cancer related cachexia play a key role in the progression and outcome of neoplastic disease. Methods cancer patients experiment design random. Subjective global assessment scoring and instrument consist WHOQOL-BREF-THAI. Sample received curcumin or fish oil 12 weeks statistic analyser Wilcoxon-Man whitney test take. Result 50-60 year old %both group 1) received curcumin group 42.85% were liver cancer diagnosis and 28.56% were colorectal cancer diagnosis treated with cancer surgery 38.09% normal body mass index 47.61% received fish oil group 33.38% were liver cancer diagnosis and were colorectal cancer diagnosis treated with cancer surgery 71.42% normal body mass index 57.14%
2) nutritional status on received curcumin intake group nutritional status mean difference score 8.00, 7.58 no significant and fish oil intake group mean difference score 8.00, 7.00 and significant p < 0.05, 95%CI 0.001-0.3) quality of life of cancer patients received curcumin intake group nutritional status mean difference score 79.00, 93.00 and significant p < 0.05, 95%CI 0.001-0.133 and fish oil intake group mean difference score 78.00, 94.00 and significant p < 0.05, 95%CI 0.001-0.133 and 4) Comparison the effect of Curcuma Longa L. and fish oil dietary intake on nutritional status of cancer patients between group pre-experimental mean difference score 8.29, 7.95 no significant and post-experimental mean difference score 6.72, 7.85 no significant comparison quality of life of cancer patients pre- experimental mean difference score 78.62, 78.86 no significant and post-experimental mean difference score 79.43, 76.29 no significant. conclusions comparison the effect of Curcuma Longa L. and fish oil dietary intake on of quality of life cancer patients no significant documented of Curcuma Longa L. dietary intake for alternative treatment on cancer patients for cachexia cancer or prevention for increasing their.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
2. Chewaskulyong B. Nutrition therapy in cancer. Journal of Nutrition. 2002;13-9 (in Thai)
3. Sripanuskul A. Perioperative nutrition support: review of published data and recommendations. Srinagarind Medical Journal. 2001;16(4):274-9. (in Thai )
4. Krusun S. How to sufficient treatment metastasis cancer. Srinagarind Medical Journal. Academic Conference 22nd Time. 2006;(21): Special issue.
5. Klinvimol T. Cancer Statistic 2012. Ubon Ratchathani Cancer Registry. 2014. p. 59 (in Thai ).
6 Hager KK. Management of weight loss in people with cancer. J Adv Pract Oncol. 2016;7(3):336–8.
7. Prapakron S, Kusiviwiliai W, Chaiyasit K. Guideline on nutrition in cancer care. Bangkok: Nursing Department, National Cancer institute; 2011. (in Thai)
8. Ruengdit S, Sunpaweravong P. Cancer anorexia-cachexia syndrome. Songklanagarind Medical Journal. 2009;27(6):503-8. (in Thai)
9. Persson C. Improved nutritional support in cancer patients. Sweden: Uppsala University; 2002.
10. Donohoe C, Ryan AM, Reynolds JV. Cancer cachexia: Mechanisms and clinical implications. Gastroenterol Res Pract. 2011;2011:601434.
11. Mantovani G, Madeddu C, Macciò A, Gramignano G, Lusso MR, Massa E, Astara G, Serpe R. Cancer-related anorexia/cachexia syndrome and oxidative stress: An innovative approach beyond current treatment. Cancer Epidemiol Biomarkers Prev. 2004;13(10):1651-60.
12. Bauer DJ, Ash S, Davidson WL, Hill JM, Brown T, Isenring EA, Reeves M. Evidence based practice guideline for the nutritional management of cancer cachexia. Nutrition & Dietetics. 2006;63(Suppl. 2):S5-32.
13. Sultan J, Griffin SM, Franco FD, Kirby JA, Shenton BK, Seal CJ, Davis P, Viswanath YKS, Preston SR, Hayes N. Randomized clinical trial of omega-3 fatty acid-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing oesophagogastric cancer surgery. Br J Surg. 2012 Mar;99(3):346-55.
14. Takayama K, Atagi S, Imamura F, Tanaka H, Minato K, Harada T, Katakami N, Yokoyama T, Yoshimori K, Takiguchi Y, Hataji O, Takeda Y, Aoe K, Kim YH, Yokota S, Tabeta H, Tomii K, Ohashi Y, Eguchi K, Watanabe K. Quality of life and survival survey of cancer cachexia in advance non-small cell lung cancer patients-Japan nutrition and QOL survey in patients with advanced non-small cell lung cancer study. Support Care Cancer. 2016;24(8):3478-80.
15. Davidson W, Ash S, Capra S, Bauer J, Cancer Cachexia Study Group. Weight stabilisation is associated with improved survival duration and quality of life in unresectable pancreatic cancer. Clin Nutr. 2004;23(2):239-47.
16. Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, MacDonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-95.
17. Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M, Gescher AJ, Steward WP. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004;10(20):6847-54.
18. Rothwell PM, Wilson M, Price JE, Belch JFF, Meade TW, Mehta Z. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet. 2012 Apr 28;379(9826):1591-601.
19. Bussink M. The role of nutrition on effectiveness of chemotherapy (Master thesis). Faculty of Science. 2012. (30 p.)
20. Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Curr Probl Cancer. 2007;31(4):243-305.
21. Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, Jee SH, Chen GS, Chen TM, Chen CA, Lai MK, Pu YS, Pan MH, Wang YJ, Tsai CC, Hsieh CY. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21(4B):2895-900.
22. Garcea G, Berry DP, Jones DJL, Singh R, Dennison AR, Farmer PB, Sharma RA, Steward WP, Gescher AJ. Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidermiol Biomarkers Prev. 2005;14(1):120-5.
23. Hsu CH, Cheng AL. Clinical studies with curcumin. Adv Exp Med Biol. 2007:595;471-80.
24. Wilken R, Veena MS, Wang MB, Srivatsan ES. Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 2011;10:12.
25. Mudge L, Isenring E, Jamieson GG. Immunonutrition in patients undergoing esophageal cancer resection. Dis Esophagus. 2011;24(3):160-5.
26. Wigmore SJ, Ross JA, Falconer JS, Plester CE, Tisdale MJ, Carter DC, Fearon KC. The effect of polyunsaturaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition. 1996;12(Suppl. 1):S27–30.
27. Wigmore SJ, Baber MD, Ross JA, Tisdale MJ, Fearon KC. Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer. Nutr Cancer. 2000;36(2):177-84.
28. Persson C, Glimelius B, Rönnelid J, Nygren P. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: A randomized pilot study. Nutrition. 2005;21(2):170-8.
29. Busquets S, Carbó N, Almendro V, Quiles M T, López-Soriano F J, Argilés J M. Curcumin, a natural product present in turmeric, decreases tumor growth but dose not behave as an anticachectic compound in a rat model. Cancer Lett. 2001 Jun 10;167(1);33-8.