Antifungal activity of ethanolic extracts from the rhizomes of Zingiberaceae plants
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Abstract
Rationale and Objective: Dermatophytosis is fungal infections of the skin caused by dermatophytes and can be treated with currently available antifungal. Moreover, the infections can be cured with medicinal plants by topical applying on the infected area. In Thai folk medicine, many plants have been claimed for the treatment of dermatitis. However, some plants still lack the scientific data for supporting the effectiveness of treatment. The objective of this study was to investigate antifungal activities of ethanolic extracts from the rhizome of plants in the Zingiberaceae family.
Methodology: The ethanolic rhizome extracts of fifteen Zingiberaceae species were tested for antifungal activities against Candida albicans and three dermatophytes i.e. Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum gypseum using broth microdilution assay.
Results: Amongst fifteen extracts, the rhizomes of Curcuma amada Roxb. and Zingiber ottensii Valeton exhibited the most potent antifungal activities against both yeast and dermatophytes with Minimum Inhibitory Concentration (MIC) values of less than 50 and 6.25 µg/mL, respectively. They showed the Minimum Fungicidal Concentration (MFC) values of 100 µg/mL to C. albicans and 3.13 - 6.25 µg/mL to T. rubrum, T. mentagrophytes, and M. gypseum.
Discussion and Conclusion: The rhizomes of C. amada and Z. ottensii showed potent antifungal activities and could kill all tested fungi. Therefore, both plants might be promising sources for isolation of antifungal substances and utilization for development of antifungal drugs from medicinal plants in further study.
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References
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