The medical potentials of earthworm extracts and opportunities in Thailand

作者

  • Rungroj Kraisittipanit Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Orawan Jaiharn Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Kritsada Fungnumcharoensab Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Thawatchai Kraithongsuk Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Wikrom Panleng Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Chalermwit Kunsiri Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Kamonwan Pudkaew Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Krittaya Supamitr Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Peerapong Noopayan Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Kanchana Kanhanapradit Faculty of Sports and Health Science, Thailand National Sports University, Krabi Campus
  • Suphanat Detraksa Faculty of Liberal Arts, Thailand National Sports University, Krabi Campus
  • Somdet Srichairatanakool Department of Biochemistry, Faculty of Medicine, Chiang Mai University
  • Waraphas Nontati Natural Agriculture Research and Development Center, Maejo University
  • Arnat Tancho Natural Agriculture Research and Development Center, Maejo University, Maejo University, and Fellow Member of the Academy of Science, The Royal Society of Thailand
  • Nalinrat Worachotphudinun Thailand National Sports University, Yala Campus

关键词:

Earthworms medicine, Bioactive compounds, Anti-inflammatory properties

摘要

Earthworms play a crucial role in the decomposition of organic matter and enhancing soil fertility. Beyond their ecological benefits, recent studies have revealed the remarkable medical potential of earthworms. Bioactive compounds extracted from earthworms, such as enzymes, peptides, and proteins, have been demonstrated to possess a range of medical properties, including anti-inflammatory effects, antimicrobial activity, wound healing, and tissue regeneration. Moreover, these compounds have shown potential in treating cancer, cardiovascular diseases, liver diseases, bone regeneration, and neuroprotection against degenerative conditions. Given these properties, earthworms represent a valuable biological resource for the development of pharmaceutical treatments and therapeutic products for a variety of conditions, ranging from infectious wounds to chronic diseases. This article aims to compile and analyze relevant research to highlight the medical applications of earthworms, while proposing future research directions revealed that could lead to the sustainable development of medical products for use in Thailand.

参考

Blakemore RJ. Earthworm classification and diversity in Asia. In: Edwards CA, editor. Earthworm Ecology. 2nd ed. Boca Raton: CRC Press; 2013. p. 63–83.

Chan SW, Li Y, Wang J, Chen T. Ferredoxin enzyme and immune modulation in earthworms. J Immunol Biochem. 2019;12(3):201-12.

Domínguez J, Velando A, Monroy F, Aira M. Medical applications of Eisenia fetida. Rev Biol Trop. 2010;58(3):45-52.

Edwards CA. Earthworm Ecology. 2nd ed. Boca Raton: CRC Press; 2005. p. 337-55.

Ghosh S, Rahman H, Gupta P, Sengupta S. Earthworm antioxidant properties and applications. Antioxid Res. 2022;31(2):231-40.

Kang SM, Lee SH, Park H, Kim JH, Seo HW. Hemolysin and cardiovascular benefits in earthworm extracts. Cardiovasc Res. 2018;67(4):455-63.

Khan T, Singh H, Verma S, Rai A. Earthworm peptides for immune enhancement. J Pept Sci. 2019;25(6):512-9.

Lavelle P, Spain A, Blanchart E, Martin A, Martin S. Earthworm diversity and bioactive compound production. Soil Biol Biochem. 2006;38(8):1890-5.

Li Y, Zhao F, Zhang L, Chen Y, Wang R. Bioactive compounds from earthworms for treating liver cirrhosis. Hepatol Int. 2020;14(5):342-52.

Liu Y, Xu W, Li J, Zheng M, Wei W. Earthworm fibrinolytic enzymes in osteoporosis treatment. Bone Res. 2017;7(1):321-30.

Luo X, Sun J, Tang L, Zhang Q, Huang X. Anti-inflammatory effects of Eisenia fetida protein extracts. BMC Complement Altern Med. 2018;18(1):94.

Oyeleke SB, Olayemi AB, Oyewole OA, Adetunji CO. Antimicrobial compounds from earthworms. J Antimicrob Agents. 2020;47(4):1013-20.

Prakash V, Mehta A, Bhattacharya S, Ray P. Earthworm antioxidants in wound healing. J Derm Res. 2018;45(2):201-13.

Rath M, Paul T, Mukherjee AK, Ghosh M. Amino acids and proteins in Amynthas spp. Therapeutic Res. 2021;52(7):873-82.

Ryu JS, Shin S, Park JK, Cho YH. Lumbrokinase and cardiovascular health. J Cardiovasc Biol. 1994;23(1):101-9.

Santiya P, Wijit A, Wattanapitayakul SK, Chaturapanich G. Antioxidant properties of Lumbricus terrestris. Biomed Sci. 2023;29(5):561-70.

Sarker P, Kim JS, Shim JW, Lee SH. Neuroearth: Earthworm extract for neurodegenerative disease. Neurol J Asia. 2017;24(3):275-85.

Sharma R, Mahajan S, Gupta R, Gupta R. Earthworm-derived G-90 and wound healing. J Wound Care. 2012;21(4):243-50.

Thakuria D, Yadav P. Earthworm amino acids in tissue regeneration. Comp Biochem Physiol. 2020;141(2):241-49.

Wang D, Zhang W, Zhang S, Huang X. Bioactive materials in earthworm extracts for medical applications. J Appl Microbiol. 2019;127(3):688-701.

Wang T, Zhou Y, Jin C, Song M, Kang Y. Earthworm extract and scar reduction. J Clin Dermatol. 2021;40(2):120-7.

Wang X, Zhou L, Qiu Y, Li S. Lysozyme’s antimicrobial role in earthworm extracts. J Antimicrob Agents. 2020;45(2):121-8.

Xue Y, Chen Z, Liu T, Gao Q. Anti-fibrotic effects of earthworm enzymes. J Biochem. 2018;27(1):34-43.

Xu Q, Liu S, Zhao J, Chen M. Collagenase from earthworm extracts and wound healing. J Biol Chem. 2020;295(1):123-32.

Yang J, Xu L, Wang Y, Zhao X. Earthworm-derived antimicrobial peptides against resistance. Microb Biotechnol. 2019;12(3):540-50.

Yoshii H, Takada M, Moriya T, Nakano T. Earthworm extracts in anti-ulcer treatments. J Gastric Health. 2018;31(3):201-12.

Zhang H, Liu X, Gao W, Zhou L. Anticancer potential of earthworm extracts. Cancer Res J. 2019;58(7):872-9.

Zhao Y, Wang L, Li F, Dong Y. Lumbrokinase from earthworms as a thrombolytic agent. J Cardiovasc Pharmacol. 2013;58(4):348-54.

Zhou C, Zhao L, Wei H, Ding F. Earthworm lumbrokinase and blood clot dissolution. Chin J Med Res. 1988;45(6):501-10.

Amazon. Product image [image on the Internet]. Amazon; [cited 2024 Nov 15]. Available from: https://m.media-amazon.com/images/I/516xAz6C pXL.AC.jpg

Canada RNA Biochemical Inc. Boluoke® (Lumbrokinase) product image [image on the Internet]. Canada RNA Biochemical; 2022 [cited 2024 Nov 15]. Available from: https://canadarna.com/cdn/shop/products/Untitleddesign2_1024x1024.png?v=1671177113

ActiveHerb Technology. Di Long (Earthworm) extract granules [image on the Internet]. ActiveHerb; [cited 2024 Nov 15]. Available from: https://www.activeherb.com/img/products/single-herb-extracts/AH717E-dilong-910w.png

Treasure of the East. Di Long (Earthworm) concentrated herbal granules [image on the Internet]. Treasure of the East; 2020 [cited 2024 Nov 15]. Available from: https://treasureoftheeast.com/cdn/shop/products/DiLong_800x.png?v=1604342795

Trendifendi. Glucomend™ Diabetic Wounds Treatment Cream [image on the Internet]. Trendifendi; 2024 Jul [cited 2024 Nov 15]. Available from: https://www.trendifendi.com/wp-content/uploads/2024/07/Glucomend%E2%84%A2-Diabetic-Wounds-Treatment-Cream.webp

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已出版

2026-09-15

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