The sedative efficacy of two combination of midazolam and hydroxyzine compares to chloral hydrate and hydroxyzine in pediatric dental patients
Keywords:
Midazolam, chloral hydrate, anterograde amnesia, anxietyAbstract
The objective of the study was to compare the safety and sedating efficacy between midazolam and chloral hydrate in pediatric patients receiving dental treatments. The randomized, crossover, and double-blinded study was performed in 50 healthy patients, age between 20 to 60 months. The subjects received equal volume of either midazolam (0.5 mg/kg) with hydroxyzine (25 mg) or chloral hydrate (50 mg/kg) with hydroxyzine (25 mg) in first visit and alternative drug in second visit. The pulse rate, respiratory rate and oxygen saturation were monitored. Anterograde memory and anxiety were evaluated at specific time points. For the results, there were no differences of physiological signs, amnesia as well as anxiety between two groups. However, midazolam had better compliance, and less side effects such as nausea, vomiting and crying which was the advantages over chloral hydrate.
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