A Study of Factors Associated with Metformin Acidosis in Type 2 Diabetes Patients Hospitalized at Nangrong Hospital, 2016-2021

Abstract

Purposes : This study incidence and factors associated with metabolic acidosis in patients with type 2 diabetes receiving metformin.

Study design : Retrospective descriptive study

Materials and Methods : 93 of sample consisted of type 2 diabetic patients receiving Metformin and receiving treatment at Nang Rong Hospital. Between October 2016 and September 30, 2021, analyzed data using statistics, percentage, mean and inferential statistics, including Chi-square test, Fisher^, s exact.

Main findings : 52.69% of diabetic patients receiving metformin had acidosis, most of them were females 53.06%, 44.90% were over 70 years old, and the duration of getting Metformin under 5 Years 57.14%, length of hospital stay was 5 - 9 days 42.86%, Metformin daily doses of 1,000 mg were 42.86%, respectively. The results of studies on the efficiency of the kidneys showed that Patients with eGFR 30 - 59 ml/min/1.73 m² had metabolic acidosis in 46.94%, followed by eGFR 60-89 ml/min/1.73 m² 28.57%, cumulative blood glucose. HbA1c ≥ 7, 71.43%, Most of the comorbidities are hyperlipidemia and hypertension 77.55%, and 65.13% respectively, and there were no factors associated with metabolic acidosis in patients with type 2 diabetes receiving Metformin, but there was a tendency for metabolic acidosis to occur in those patients with impaired renal function despite receiving a small dose of medication or patients who control their blood sugar levels well.

Conclusion and recommendations : Therefore kidney function, eGFR, serum creatinine values should be monitored every 3 - 6 months in patients receiving metformin to help reduce the chances of The severity and prevention of metabolic acidosis