DEVELOPMENT AND EFFECTIVE EVALUATION OF A MEDICATION ADHERENCE ON SCHIZOPHRENIA PATIENTS
Keywords:
schizophrenia patients, medication adherenceAbstract
Abstract
Objectives: To develop and evaluate a program to promote adherence to medication for patients with schizophrenia.
Material and Methods: Research and development were conducted in three phases: Phase 1: Needs assessment for development; Phase 2: Research and development to develop a program prototype and assess the quality from content validity evaluation; Phase 3: Quasi-experimental research with two groups measuring before, after, and follow-up to evaluate and compare the program's results in patients with schizophrenia. Data were analyzed using descriptive statistics and repeated-measure ANOVA.
Results: Phase 1: Stakeholder interviews revealed that service providers wanted to increase the coverage of activities to include relatives. Phase 2: Developing a prototype of a program to promote adherence to medication for schizophrenia patients, consisting of six 60-minute group sessions. Phase 3: A total of 100 participants (50 patients and 50 caregivers) were divide into experimental and control group, with 25 participants each. It was found that over time, the experimental group's medication adherence behavior scores in the immediate post-experiment period and the 1-month follow-up period significantly improved compared to the control group (p<0.001).
Conclusion: The program effectively promotes medication adherence among patients with schizophrenia.
References
World Health Organization. Schizophrenia 2022. [online]. Available from: https://www.who.int/news-room/fact-sheets/
detail/schizophrenia [2022 Jul 9].
Tandon R, Gaebel W, Barch DM, et al. Definition and description of schizophrenia in the DSM-5. Schizophr Res 2013; 150: 3-10.
Khampuansai S. Results of the program for caring for psychiatric patients by families to reduce stress in caring for caregivers of patients with schizophrenia Thung Saliam Hospital Sukhothai Province [Master's thesis]. Chiang Mai: Chiang Mai University; 2007.
Bunkhan B. Factors of perception and social support of caregivers of schizophrenia patients that are related to drug treatment behavior of schizophrenia patients in Amnat Charoen Province [Master's thesis]. Ubon Ratchathani: Ubon Ratchathani Rajabhat University; 2010.
Department of Mental Health. Annual report of the Department of Mental Health. [online]. Available from: https://dmh-elibrary.org/items/show/334 [2020 May 10].
Sadock BJ, Sadock VA. Kaplan & Sadock's Concise Textbook of Clinical Psychiatry. 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2007.
Hill M, Crumlish N, Whitty P, Clarke M, Browne S, Kamali M, et al. Nonadherence to medication four years after a first episode of psychosis and associated risk factors. Psychiatr Serv 2010; 61: 189-92.
Kassis I, Ghuloum S, Mousa H, Bener A. Treatment non-compliance of psychiatric patients and associated factors: Are patients satisfied from their psychiatrist? J Adv Med Med Res 2014; 4: 785-96.
Saboo AV, Deshmukh PS, Deshmukh SB. Study on non-compliance in patients of schizophrenia. J Evol Med Dent Sci 2015; 4: 8112-9.
Novick DM, Swartz HA, Frank E. Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 2010; 12: 1-9.
Policy and Planning Department, Loei Rajanagarindra Psychiatric Hospital. Patient statistics for the year 2021. Loei: Loei Rajanagarindra Psychiatric Hospital; 2021.
Suntharawit N, Wichitpanya A, Inkantum P. Effects of health promotion programs on health behavior for cooperation in drug treatment of schizophrenia patients. J Psychiatr Ment Health Nurs 2020; 34: 153-68.
El-Mallakh P, Findlay J. Strategies to improve medication adherence in patients with schizophrenia: the role of support services. Neuropsychiatr Dis Treat 2015; 11: 1077-90.
Saengpak C, Thungpankham P, Kitsamban W. Effects of treatment for continuous medication adherence on cooperation in drug treatment in people with schizophrenia in the community. Nursing Journal CMU 2017; 44(1): 137-48.
Von Bormann S, Robson D, Gray R. Adherence therapy following acute exacerbation of schizophrenia: A randomized controlled trial in Thailand. Int J Soc Psychiatry 2015; 61: 3-9.
Thanabadeethamcharee P, Temrasi B. Development of a program to promote awareness of illness and belief in taking medicine towards cooperative behavior in taking medicine of patients with schizophrenia. The Journal of Psychiatric Nursing and Mental Health 2018; 32(3): 133-53.
Pender NJ. Health Promotion in Nursing Practice. 5th ed. New Jersey: Pearson Education; 2006.
Miller WR, Rollnick S. Motivational interviewing: preparing people for change. 2nd ed. New York: The Guilford Press; 2002.
Beck AT, Rector NA. Cognitive approaches to schizophrenia: theory and therapy. Ann Rev Clin Psychol 2005; 1: 577-606.
Becker MH, Maiman LA. The Health Belief Model: origins and correlates in psychological theory. Health Educ Monogr 1975; 2: 336-85.
Palitnonkiat Y, Khunkamchu P, Ruchirachakorn S, Saetang S, editors. Manual for research and development of mental health technology. Nonthaburi: Best Step Advertising Company; 2011.
Chien WT, Mui JH, Cheung EF, Gray R. Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders: a randomized controlled trial. Trials 2015; 16: 270.
Weiden P, Turkington D, Mihailovic M, Beaumont J. Medication adherence in schizophrenia: development of a CBT-based intervention 2019. [online]. Available from: https://www.researchgate.net/publication/333815675
Barkhof E, Meijer CJ, de Sonneville LM, Linszen DH, de Haan L. Interventions to improve adherence to antipsychotic medication in patients with schizophrenia--a review of the past decade. Eur Psychiatry 2012; 27(1): 9-18.
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