Comparison Effectiveness of SAR-CoV-2 vaccine in Healthcare Workerat Nonsang Hospital Nong Bua Lumphu Province

Abstract

This research was a study on the effectiveness comparison of the SAR-CoV-2 vaccine in healthcare workers at Nonsang hospital, Nong Bua Lamphu province. This research was a prospective observational study to monitor the level of immunity in healthcare workers following the 4th booster dose and above. The data was secondary data. The sample group was specifically selected as 89 healthcare workers, and only 7 healthcare workers were selected to collect both quantitative and qualitative data from in-depth interviews. We presented the data with descriptive statistics such as frequency, percentage, maximum, minimum, mean, and univariate analysis. The adjusted odds ratio with Spearman Rank (rs) was added in this research. The information was brought modeled by linear regression and comparatively analyzed of immune levels with repeated one-way ANOVA. The finding revealed that gender (rs = 0.292, p-value = 0.006) and age (rs = 0.234, p-value = 0.027) were related to the immune level from 2 doses of inactivated vaccine in a low positive direction with statistically significant at the 0.05 level. Sex (rs = 0.280, p-value = 0.008), triglycerides (TG) (rs = 0.262, p-value = 0.013), and vaccine type (rs = 0.391, p-value < 0.001) were related to an increase in immunity from three doses of inactivated vaccine in a low positive direction with statistically significant at the 0.05 level. The samples who had normal BMI (ORadj=0.174; 95%CI=0.03-0.90), normal cholesterol levels (ORadj=0.174; 95%CI=0.03-0.90) and received booster (5th dose) vaccination (ORadj = 0.158; 95%CI = 0.02-0.88) were likely to be infected COVID-19 less than an abnormal group of samples and samples who received booster (3rd dose) vaccination. Receiving a booster (5th dose) vaccination would increase higher immunity level, which could decrease the hospitalization rate and mortality rate from COVID-19. Recommendations were that healthcare workers should receive vaccination with a booster dose (5th dose), and awareness and understanding of the benefits of each vaccine should be created, to see the importance of vaccination to prevent and reduce the severity of COVID-19.