Factors affecting methylphenidate adherence in children and adolescent with attention deficit hyperactivity disorder

บทคัดย่อ

Objective  To study the association of factors affecting medication adherence in children and adolescent with attention deficit hyperactivity disorder (ADHD).

Materials and methods  This research was a cross-sectional descriptive study. ADHD patients (age 8-18 years) at Yuwaprasart Waithayopathum Child Psychiartric Hospital during 1 December 2013 to 30 March 2014 were enrolled in this study. Instruments were applied by self-administered and interviewed questionnaires for parents i.e. general information, assessment of knowledge and attitude towards treatment ADHD, medication adherence and adverse drug reactions and interviewed questionnaires for patients i.e. assessment the attitudes about ADHD and medication adherence.

Results  There were 150 cases, of these 76.7% were male and average age of 11.6 years. Average duration of treatment with methylphenidate was 3.3 years and the frequency of drug administration was twice times a day (68.7%).The result of this study were found that 43.3% of patients had most of medication adherence scores in the moderate level. Stepwise multiple regression analysis revealed that age of patient, ability to swallow medicine, frequency of drug administration were significantly predictors of medication adherence in children and adolescent with ADHD 51% . Younger patients, can swallow medicine, dosage form (Extended-release) and the frequency of drug administration rarely were associated with medication adherence.

Conclusion Factors associated to medication adherence found from this study can be implemented for monitoring on medication uses and predicted the association with medication adherence for ADHD patients.