Main Article Content
Objective To identify the parameters for calculating burden of diseases in mood disorders including major depressive disorder (MDD), dysthymia, and bipolar disorder (BD)
Material and method The literatures were searched through PubMed, Scopus, Cochrane library, and BMJ databases published after the 1990s using keywords such as major depressive disorder, dysthymia, bipolar or mania or hypomania or mood, prevalence, incidence, duration, recovery, remission,
recurrence, mortality rate, disability weight (DW), burden of disease, YLDs, and DALYs. The retrieved publications were screened and selected. Then, the data were analyzed and synthesized for appropriate parameters.
Results Twelve-month prevalence of MDD, dysthymia, and BD in male/female was 0.96%/2.43%, 0.07%/0.17%, and 0.05%/0.39% respectively. Incidence rates of MDD, dysthymia, and BD were 3 per 100 person-year, 3.4 per 100 person-year, and 0.59 per 100,000 person-year, respectively. The ages of
onset of MDD and dysthymia were 40.35 years and 40.67 years, while age of onset of BD was between 15-24 years and 45-54 years. The duration of illness of MDD, dysthymia, and BD in Thailand was 0.79 years, 8 years, and 2-3 months respectively. The lifetime episodes of MDD, dysthymia, and BD were 6.12, 3.7, and 5.44 times. Relative risks of mortality of MDD, dysthymia and bipolar were 1.9, 1.42, and 2.05. Overall DW for MDD was 0.23. DW for dysthymia was 0.14 whereas DW for BD based on episodes whether depressive (0.40), manic (0.49), or residual (0.03).
Conclusion The parameters available for calculating the burden of mood disorders in Thailand were prevalence, age of onset, duration of illness, and lifetime episodes. The future research in Thailand should study on other parameters including incidence, remission rate, recurrent rate, relative risk mortality
and disability weight which data in Thailand are available.
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