Efficacy between sertraline GPO and the original drug in treatment of major depressive disorder

บทคัดย่อ

Objective  To compare efficacy, side effect and dosage between sertraline GPO and the original drug in treatment of  major depressive disorder.

Materials and Methods   This non-randomized controlled trial study was performed  in  34  major depressive patients aged 20-59 years. The samples were allocated  into two groups by type of reimbursement. Sertraline GPO was prescribed for 18 cases as the study group and original drug was for 16 cases as the control group. All cases were assessed depression score by Montgomery-Asberg Depression Rating Scale at baseline, 4^th week and endpoint (8^th week). Response rate, remission rate, side effect and mean dose were assessed at 4^th and 8^th weeks.

Results  There were no significant differences in response and remission rates at 4^th and 8^th weeks. The mean dose of the control group was significantly higher than that of sertraline GPO. The most frequently reported side effects were sedation, tremor, dry mouth, decreased libido, weight gain and nausea.

Conclusion There were no differences in efficacy between sertraline GPO and the  original drug. However, there were  some limitations of  this study. Further study was suggested.