Incidence and Analysis of factors related to Thyroid Cancer in Patients Undergoing Surgery at the Otolaryngology Department at Krathum Baen Hospital

Authors

  • สุทธิพันธ์ ดำริห์ศิลป์ กลุ่มงานหู คอ จมูก โรงพยาบาลกระทุ่มแบน จังหวัดสมุทรสาคร

Keywords:

Thyroid cancer, Cancer risk factors

Abstract

Objective: To study the incidence and types of thyroid cancer and to analyze factors related to thyroid cancer in patients undergoing surgery at the otolaryngology department at  Krathum Baen hospital

Materials and methods: A retrospective study was conducted from January 1, 2013 to October 31, 2021 on 212 patients undergoing thyroidectomy at Krathum Baen hospital. Data were analyzed using multivariable logistic regression to evaluate the associated clinical factors of thyroid cancer. Data analysis was performed by the SPSS23. The significance level was set at P<0.05.

Results: From 212 patients who underwent thyroid surgery, 182 (85.85%) were female. Pathological findings showed malignancy in 53 (25%) of the patients, 47 (88.6%) of thyroid cancer were papillary thyroid carcinoma. Multivariate logistic regression showed some physical examinations, firmness to palpation (P<0.001, OR 83.8), fixation of thyroid nodule at adjacent tissues (P<0.001, OR 268.2), cervical lymphadenopathy (P<0.001, OR 63.368) could predict malignancy in the patients with thyroid nodules.

Conclusion: Firmness to palpation, fixation of thyroid nodule at adjacent tissues, cervical lymphadenopathy were statistically significant factors to predict malignancy in the patients with thyroid nodules in this study.

Keywords: Thyroid cancer, Cancer risk factors

References

1. KIM ES, Lim DJ, Back KH, Lee JM, Kim MK ,et al. Thyroglobulin antibody is associated with increased cancer risk in thyroid nodule. Thyroid.2010 Aug;20(8):885-91
2. Syrenicz A, Koziolek M , Ciechanowicz A ,et al. New insights into the diagnosis of nodular goiter. Thyroid Res.2014 Jan 17;526-7
3. Laszlo Hegedus. The Thyroid nodule. N Engl J med.2004,351:1764-71
4. Giulic C , Zubair W. Preoperative Diagnosis of Benign Thyroid Nodules with indeterminate Cytology. N Engl J Med.2012 Aug 23:367 ; 705-715
5. Davies L , Weich HG . Increasing incidence of thyroid cancer in the United states 1973-2002. JAMA 2006; 295: 2164-7
6. J. Rojanamatin, W. Ukranun, P.suppattagorn, et al. Cancer in Thailand 2016-2018 . Bangkok 2021 ;10: 60-61
7. Steven R. Bomeli , Shane O. LeBeau , Robert L Ferris. Evaluation of a thyroid nodule. Otolaryngol-Clin North Am 2010 Apr;43(2):229-238
8. Bryan R. Haugen, 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Diffentiated Thyroid Cancer. The American Thyroid Associaion Guideline2016;26:1-133
9. Cooper DS, Doberty GM , Haugen BR, et al . Management Guidelines for Patients with Thyroid Nodules and differentiated Thyroid Cancer. Thyroid 2006;20(2):1-33
10. https://rdo.psu.ac.th/ResearchStandards/animal/assets/document/SampleSizes.pdf
11. อิสรพงศ์ ทรัพย์ชวโรจน์ . ความชุกของการเกิดโรคมะเร็งในก้อนที่คลำได้และได้รับการผ่าตัดของต่อมไทรอยด์ ณ โรงพยาบาลเจริญกรุงประชารักษ์. วารสารโรงพยาบาลเจริญกรุงประชารักษ์. 2012;8(1):1-11
12. พรปณิธาน สมเจริญวัฒนา. ปัจจัยเสี่ยงต่อการเกิดมะเร็งต่อมไทรอยด์ในผู้ป่วยที่มารับการผ่าตัดที่แผนกหู คอ จมูก โรงพยาบาลพัทลุง. วารสารวิชาการแพทย์ เขต 11. 2015;29:633-640
13. Maturo A. Incidental Thyroid Carcinoma. A Retrospective Study. G Chir 2017;38(2):94-101
14. Mohammed AbdulHassain. Incidental Thyroid Carcinoma in Patients Presumably Operated for Benign Thyroid Diseases. Bahrain Medical Bullentin.2020;42(5):199-201
15. Laszlo Hegedus. The thyroid nodule. N Eng J Med 2004;351:1764-171
16. Davies L , Welch HG. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg.2014;140(4):317-22.doi:10.1001/jamaoto.2014.1.
17. Papini E, Guglielmi R , Bianchini A , Crescenzi A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab.2002;87(5):1941-6.
18. Zahra D, Arezoo C, Hooman B , Karim B . Can clinical presentation and ultrasonography predict the risk of malignancy in thyroid nodules?. Middle East Journal of Cancer;July 2019;10(3):246-253

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Published

2022-05-03

How to Cite

ดำริห์ศิลป์ ส. (2022). Incidence and Analysis of factors related to Thyroid Cancer in Patients Undergoing Surgery at the Otolaryngology Department at Krathum Baen Hospital. Hua Hin Medical Journal, 2(1), 22–33. Retrieved from https://he01.tci-thaijo.org/index.php/hhsk/article/view/253635

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Original article