Times Period of Treatment of COVID -19 Patient in Rayong Hospitals, Thailand
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Abstract
Retrospective Cohort Study estimates length of hospital stay, and factors related to COVID-19 treatment (Discharge free survival) of COVID-19 patients in Rayong Province, from data on infected and those who have been in contact with COVID-19 recorded on a computer with RT-PCR test results. The results are detected between December 1, 2019 to January 31, 2021, there were 404 infected and 174 contacts with COVID-19. Kaplan-Meier analysis was used to estimate length of stay and Log rank test to test the differences between the graphs. with time of stay for treatment, Cox’s Regression with Hazard ratio, factors related to patient discharge, Cox proportional hazard model, interpreting results and comparing according to variables. The results were different from the time of discharge, with p-value < 0.05. Kaplan-Meier results, median survival time, treatment stay was 15.97 days (95% CI =16.87 - 19.12). The main symptom was cough. Interpret Log rank test results patient, PUI (Patients Under Investigation) and CC (Contact Cases) hospital stay (Rayong hospital, field hospital, other government hospitals and Private hospitals) and residences (Muang district, Rayong and other districts) were related to length of stay (p< 0.0001, p<0.0001 and p<0.0001 respectively). Multivariate analysis: men has a chance of being discharged quickly 1.21 times more than women (adj HR=1.21, 95% CI =1.02 - 1.43, p=0.027). Patients infected with PUI have a chance of being discharged 1.64 times quickly than Patients infected with CC (adj HR= 1.64, 95% CI =1.36 - 1.98, p<0.0001). Living in Mueang Rayong district has a chance of being discharged quickly 0.66 times higher than other districts (adj HR=0.66, 95% CI= 054 - 0.79, p<0.0001) and stay in other government hospitals and private hospitals have a chance of being discharged later than Rayong hospitals and field hospitals 0.66 times (adj HR=0.66, 95% CI 0.47 - 0.92, p<0.0150) and 0.63 times (adj HR=163, 95% CI= 0.43 - 0.90, p=0.0130), respectively. The results of the study support treatment planning and prevention of the spread of infection in hospitals and communities.
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References
Harmooshi NN, Shirbandi K, Rahim F. Environmental concern regarding the effect of humidity and temperature on 2019-nCoV survival: fact or fiction. Environ Sci Pollut Res Int 2020; 27(29): 36027-36036. doi: 10.1007/s11356-020-09733-w.
Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature 2020; 584(7821): 430-436. doi: 10.1038/s41586-020-2521-4.
Filardo TD, Khan MR, Krawczyk N, Galitzer H, Karmen-Tuohy S, Coffee M, Schaye VE, Eckhardt BJ, Cohen GM. Comorbidity and clinical factors associated with COVID-19 critical illness and mortality at a large public hospital in New York City in the early phase of the pandemic (March-April 2020). PLoS One 2020; 15(11): e0242760. doi: 10.1371/journal.pone.0242760.
Grasselli G, Greco M, Zanella A, et al. Cecconi M; COVID-19 Lombardy ICU Network. Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy. JAMA Intern Med 2020; 180(10): 1345-1355. doi: 10.1001/jamainternmed.2020.3539.
Ramírez P, Gordón M, Martín-Cerezuela M, Villarreal E, , et al. Acute respiratory distress syndrome due to COVID-19. Clinical and prognostic features from a medical Critical Care Unit in Valencia, Spain. Med Intensiva (Engl Ed) 2021; 45(1): 27-34. doi: 10.1016/j.medin.2020.06.015.
Challen R, Brooks-Pollock E, Read JM, Dyson L, Tsaneva-Atanasova K, Danon L. Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study. BMJ 2021; 372: n579. doi: 10.1136/bmj.n579.
Surendra H, Elyazar IR, Djaafara BA, Ekawati LL, et al. Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study. Lancet Reg Health West Pac 2021 ;9 :100108. doi: 10.1016/j.lanwpc.2021.100108.
Chua GT, Xiong X, Choi EH, Han MS, Chang SH, Jin BL, et al. COVID-19 in children across three Asian cosmopolitan regions. Emerg Microbes Infect 2020; 9(1): 2588-2596. doi: 10.1080/22221751.2020.1846462.
Sim BLH, Chidambaram SK, Wong XC, Pathmanathan MD, Peariasamy KM, Hor CP, Chua HJ, Goh PP. Clinical characteristics and risk factors for severe COVID-19 infections in Malaysia: A nationwide observational study. Lancet Reg Health West Pac 2020; 4: 100055. doi: 10.1016/j.lanwpc.2020.100055.
Laxminarayan R, Wahl B, Dudala SR, Gopal K, Mohan B C, Neelima S, Jawahar Reddy KS, Radhakrishnan J, Lewnard JA. Epidemiology and transmission dynamics of COVID-19 in two Indian states. Science 2020; 370(6517): 691-697. doi: 10.1126/science.abd7672.
Department of Disease Control, Ministry of Public Health. Fact Sheet of EOC Conference in province level. [internet]. 2020 [cited 2021 May 15]. Available from: https://ddc.moph.go.th/index.php (in Thai)
Rayong Provincial of Public Health. Situation of Coronavirus-2019 Infection Disease on Dialy: Fact Sheet of EOC Conference in Rayong province on December 15, 2020 to May 15, 2021. [internet]. 2020 [cited 2021 May 15]. Available from: https://rayong.moph.go.th/cdc/ (in Thai)
Yue H, Bai X, Wang J, Yu Q, Liu W, Pu J, et al. Clinical characteristics of coronavirus disease 2019 in Gansu province, China. Ann Palliat Med 2020; 9(4): 1404-1412. doi: 10.21037/apm-20-887.
Anderson MR, Bach PB, Baldwin MR. Hospital Length of Stay for Patients with Severe COVID-19: Implications for Remdesivir's Value. Pharmacoecon Open 2021; 5(1): 129-131. doi: 10.1007/s41669-020-00243-6.
Rayong Provincial of Public Health. Situation of Coronavirus-2019 Infection Disease on Dialy. Fact Sheet of EOC Conference in Rayong province on April 16, 2020. [internet]. 2020 [cited 2021 May 15]. Available from: https://rayong.moph.go.th/cdc/ (in Thai)
World Health Organization (WHO). Novel Coronavirus(2019-nCoV). [internet]. 2020 [cited 2021 May 15]. Available from:
Byeon KH, Kim DW, Kim J, Choi BY, Choi B, Cho KD. Factors affecting the survival of early COVID-19 patients in South Korea: An observational study based on the Korean National Health Insurance big data. Int J Infect Dis 2021; 105: 588-594. doi: 10.1016/j.ijid.2021.02.101.
Bruminhent J, Ruangsubvilai N, Nabhindhakara J, Ingsathit A, Kiertiburanakul S. Clinical characteristics and risk factors for coronavirus disease 2019 (COVID-19) among patients under investigation in Thailand. PLoS One 2020; 15(9): e0239250. doi: 10.1371/journal.pone.0239250.
Liu T, Liang W, Zhong H, He J, Chen Z, He G, et al. Risk factors associated with COVID-19 infection: a retrospective cohort study based on contacts tracing. Emerg Microbes Infect 2020; 9(1): 1546-1553. doi: 10.1080/22221751.2020.1787799
Jiang N, Liu YN, Bao J, Li R, Ni WT, et al. Clinical features and risk factors associated with severe COVID-19 patients in China. Chin Med J (Engl) 2021 Apr 1;134(8): 944-953. doi: 10.1097/CM9.0000000000001466.
Thai PQ, Toan DTT, Son DT, Van HTH, Minh LN, Hung LX, et al. Factors associated with the duration of hospitalisation among COVID-19 patients in Vietnam: A survival analysis. Epidemiol Infect 2020; 148: e114. doi: 10.1017/S0950268820001259.
Kaufman BG, Whitaker R, Pink G, Holmes GM. Half of Rural Residents at High Risk of Serious Illness Due to COVID-19, Creating Stress on Rural Hospitals. J Rural Health 2020 ; 36(4): 584-590. doi: 10.1111/jrh.12481.
Márquez-González H, Méndez-Galván JF, Reyes-López A, Klünder-Klünder M, Jiménez-Juárez R, Garduño-Espinosa J, Solórzano-Santos F. Coronavirus Disease-2019 Survival in Mexico: A Cohort Study on the Interaction of the Associated Factors. Front Public Health 2021; 9: 660114. doi: 10.3389/fpubh.2021.660114.