Prevalence and Associated Factor of Post COVID Conditions After Infected with SARS-CoV-2

Main Article Content

Charenthon Phongthanu
Siriwat Buaruang
Permpen Noitoon

Abstract

      This study aimed to investigate the prevalence of Post COVID Conditions and study factors related to post COVID conditions after being infected with SARS-CoV-2 among Thai patients in Bangkok metropolitan region between September 2021 and September 2022. A questionnaire adapted from the Global COVID-19 Clinical Platform Case Report Form for Post COVID condition (Post COVID-19 CRF) was used to collect personal information and details about post COVID conditions data from 351 patients, divided into two groups: those experiencing symptoms 4-12 weeks post-infection (187 cases) and those with symptoms persisting beyond 12 weeks post-infection (164 cases). The study found a prevalence of at least one post COVID condition at 75.94% and 82.92% in the 4-12 weeks and beyond 12 weeks groups, respectively. Fatigue, cognitive impairment, insomnia, and dry cough were the most common symptoms. Additionally, female participants were more likely to experience post COVID condition, difficulty doing activities, and decreased self-care ability compared to males (p < 0.05, logistic regression). Although post COVID conditions were not severe or acute, they could impact quality of life. Therefore, screening for risk factors and continuous symptom monitoring are recommended. However, the results of this study can provide a foundation for designing future research with larger and more diverse samples.

Article Details

How to Cite
Phongthanu, C., Buaruang, S., & Noitoon, P. (2025). Prevalence and Associated Factor of Post COVID Conditions After Infected with SARS-CoV-2. Journal of Bamrasnaradura Infectious Diseases Institute, 19(2), 88–99. https://doi.org/10.14456/jbidi.2025.9
Section
Original Articles

References

WHO. Number of COVID-19 cases reported to WHO (cumulative total)[internet]. 2024 [cited 2024 April 8]. Available from: https://data.who.int/dashboards/covid19/cases?n=c

WHO. Coronavirus Disease 2019 Situation in Thailand [internet]. 2024 [cited 2024 April 8]. Available from: https://www.who.int/thailand/news/detail/07-02-2024-update-on-covid-19-in-thailand--7-february-2024-THA

WHO. Transmission of SARS-CoV-2: implications for infection prevention precautions [internet]. 2020 [cited 2021 August 29]. Available from: https://apps.who.int/iris/bitstream/hadle/10665/333114/WHO-2019-nCoV-Sci_Brief-Transmission_modes-2020.3-eng.pdf

Zhou L, Ayeh SK, Chidambaram V, Karakousis PC. Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions. BMC Infectious Diseases 2021; 21(1): 496.

Duong D. Alpha, Beta, Delta, Gamma: What's important to know about SARS-CoV-2 variants of concern? Cmaj 2021; 193(27): E1059-60.

McIntosh K. COVID-19: Clinical features [internet]. 2021 [cited 2021 August 29]. Available from: https://www.uptodate.com/contents/covid-19-clinical-features#H4100426989

Zhang N, Xie T, Ning W, He R, Zhu B, Mao Y. The Severity of COVID-19 and Its Determinants: A Systematic Review and Meta-Analysis in China. Sustainability 2021; 13(9): 5305.

Centers for Disease Control and Prevention. Evaluating and caring for patients with post-COVID conditions : interim guidance : patient history and physical exam [internet]. 2021 [cited 2024 April 8]. Available from: https://stacks.cdc.gov/view/cdc/107148.

Sk Abd Razak R, Ismail A, Abdul Aziz AF, Suddin LS, Azzeri A, Sha’ari NI. Post-COVID syndrome prevalence: a systematic review and meta-analysis. BMC Public Health 2024; 24(1): 1785.

Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, et al. Post-acute COVID-19 syndrome. Nature Medicine 2021; 27(4): 601-15.

Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Florencio LL, Cuadrado ML, Plaza-Manzano G, et al. Prevalence of post-COVID-19 symptoms in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis. Eur J Intern Med 2021; 92: 55-70.

National Health Service. Long-term effects of coronavirus (long COVID) [internet]. 2021 [cited 2021 August 29]. Available from: https://www.nhs.uk/conditions/coronavirus-covid-19/long-term-effects-of-coronavirus-long-covid/

Pavli A, Theodoridou M, Maltezou HC. Post-COVID Syndrome: Incidence, Clinical Spectrum, and Challenges for Primary Healthcare Professionals. Arch Med Res 2021; 52(6): 575-81.

Chopra V, Flanders SA, O'Malley M, Malani AN, Prescott HC. Sixty-Day Outcomes Among Patients Hospitalized With COVID-19. Ann Intern Med 2021; 174(4): 576-8.

Huang C, Huang L, Wang Y, Li X, Ren L, Gu X, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021; 397(10270): 220-32.

Arnold DT, Hamilton FW, Milne A, Morley AJ, Viner J, Attwood M, et al. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a prospective UK cohort. Thorax 2021; 76(4): 399-401.

Moreno-Pérez O, Merino E, Leon-Ramirez JM, Andres M, Ramos JM, Arenas-Jiménez J, et al. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. J Infect 2021; 82(3): 378-83.

Jacobs LG, Gourna Paleoudis E, Lesky-Di Bari D, Nyirenda T, Friedman T, Gupta A, et al. Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection. PLoS One 2020; 15(12): e0243882.

Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H, et al. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect 2020; 81(6): e4-e6.

Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol 2021; 93(2): 1013-22.

Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49(12): 1373-9.

Phu DH, Maneerattanasak S, Shohaimi S, Trang LTT, Nam TT, Kuning M, et al. Prevalence and factors associated with long COVID and mental health status among recovered COVID-19 patients in southern Thailand. PLoS One 2023; 18(7): e0289382.

Rutjanawech S, Sritipsukho P, Sritipsukho S. Long COVID at 3 and 6 months after covid-19 infection in Thailand. Scientific Reports 2024; 14(1): 23441. (in Thai)

Bai F, Tomasoni D, Falcinella C, Barbanotti D, Castoldi R, Mulè G, et al. Female gender is associated with long COVID syndrome: a prospective cohort study. Clin Microbiol Infect 2022; 28(4): 611.

Juszko K, Szary P, Mazurek J, Rutkowski S, Cies´lik B, Szczepan´ska-Gieracha J, et al. Long-Term Consequences of COVID-19 Disease Specific to Women: Exploratory Research. Int J Environ Res Public Health 2022; 20(1).

Zeng F, Dai C, Cai P, Wang J, Xu L, Li J, et al. A comparison study of SARS-CoV-2 IgG antibody between male and female COVID-19 patients: A possible reason underlying different outcome between sex. J Med Virol 2020; 92(10): 2050-4.