Outcome of Kae Lom Kae Sen for Pain Relief in Patients with low back pain: An observational study
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Abstract
Introduction and Objective: Kae Lom Kae Sen has the properties of relieving muscle pain, fatigue, muscle stiffness, and numbness, serving as a traditional Thai herbal medicine formula making it one of the top 3 most used cannabis formula in Thailand medical cannabis clinics. However, there has been no study on its clinical outcome and side effect methodically. This study aims to evaluate the outcome and adverse drug reaction of using Kae Lom Kae Sen in outpatients with low back pain symptoms at the Hang-Ka-Rok Clinic, Pra Arjan Phan Arjaro Hospital.
Methods: The study was conducted through a prospective observational study on outpatients receiving treatment for low back pain. A total of 60 patients were included between June 2020 and May 2021. The sample group received Kae Lom Kae Sen, packaged in sachets of 2 g each, to be taken once a day, 1 sachet mixed with honey, Citrus anrantium juice, or warm boiled water, taken twice a day before meals, morning and evening, continuously for 4 weeks. The sample group was scheduled for follow-up to assess treatment outcomes, including pain intensity scores (Visual Analogue Scale: VAS), adverse events from medication, and overall treatment satisfaction.
Results: 93.33% of the sample group experienced improved lowback pain symptoms after completing one week of treatment, with statistically significant reductions in average pain intensity scores before and after completing 4 weeks of Kae Lom Kae Sen treatment, from 7.57 ± 1.24 points to 3.18 ± 1.14 points, respectively. The most common adverse events from drug were heartburn (16.67%), dry mouth, feel dry (5.00%), and dizziness (1.67%). The average overall treatment satisfaction score for Kae-Lom-Kae-Sen treatment was 4.51 ± 0.62 points.
Discussion: Kae Lom Kae Sen can reduce the pain score. This may be a result of the pharmacological effects of important herbal substances in the formula that have analgesic effects and anti-inflammatory. The main flavor ot the recipe is very hot. Let the blood flow to various organ and increase body warmth.
Conclusionand Recommendation: The research results indicate that Kae Lom Kae Sen can effectively alleviate muscle pain symptoms in the sample group, as assessed by reduced pain intensity scores, along with safety among the sample group using the medicine continuously for one month.
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