The Study on Effectiveness of Gel Patches Containing Yapoktongnoikublohit Extract on Pain Relief in Primary Dysmenorrhea
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Abstract
Introduction and objectives: Yapoktongnoikublohit (YTK) recipe is in a traditional Thai medicine text used for pain relief in primary dysmenorrhea. Therefore, it is suitable for use as an essential ingredient in a gel patch formula to reduce painful periods. This study aimed (1) to determine the physical stability, (2) to evaluate skin irritation, (3) to test the efficacy, and (4) to evaluate users’ satisfaction with YTK-containing gel patch for pain relief in primary dysmenorrhea.
Methods: The gel patch was prepared using Cissampelos pareira (khruea ma noi in Thai) extract, YTK extract, and gelatin. We used a patch test for skin irritation evaluation in 30 participants. The cross-over study was used to evaluate the efficacy of the gel patch with three treatments: YTK poultice, gel patch, and YTK gel patch. Menstrual pain levels were assessed using the visual analogue scale (VAS) at 30 minutes, 1 hour, and 4 hours after treatment.
Results: The best formula contained 69.56% w/w C. pareira extract, 17.40% w/w YTK extract, and 13.04% w/w gelatin. The skin test did not show any skin irritation. The YTK patch could relief menstrual pain significantly (p-value ≤ 0.05) compared with other treatments. And the users’ satisfaction level with the YTK patch was high.
Discussion: Previous studies have shown that the ingredients of the YTK formula were found to inhibit the process of prostaglandin synthesis, inhibit the enzyme cyclooxygenase-1 and cyclooxygenase-2, and reduce inflammation.
Conclusion and recommendation: The YTK gel patch can be developed in the form that is convenient for use and can be carried easily. Moreover, it can also be further used by small-sized enterprises in preparing or producing other products.
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