Development of Pandanus amaryllifolius Extract Pellets for Dental Plaque Disclosing
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Abstract
This study aimed to develop natural plaque disclosing pellets containing extract of Pandanus amaryllifolius leaves. The green extract was obtained from water extraction without heating and then freeze-dried. Pandan pellets containing pandan extract and various fillers were then prepared by the extrusion-spheronization method. Suitable pellet formulations were chosen based on their sphericity as well as plaque-disclosing abilities, tested for disintegration and friability, and kept at ambient temperature for a 1-month stability study. The results showed that the type of fillers influenced the sphericity and plaque-disclosing abilities of pandan pellets. Mordant also influenced the plaque-disclosing ability. The formulation containing 15% pandan extract, a blend of Avicel RC-591 and Avicel PH101 (70:30) and 10% alum gave satisfactory pellets disintegrated readily; and the friability test result was less than 1%. The pandan pellets exhibited no physical changes, and their chlorophyll content remained higher than 90% after 1-month storage. This study showed promising results for the pandan pellets as a natural disclosing agent for dental plaque.
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