Biological and Anticancer Activities as well as Total Phenolic Content of Thai Traditional Herbal Medicine for Treatment of Uterine Cancer
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Abstract
Ya Kae Mareng Nai Motluk (MRM) is a Thai traditional herbal remedy for uterine cancer, described in the textbook on herbal medicine by folk healer Mor Phon, Krom Luang (Prince) Chumphon Khet Udomsak. As biological activities of this remedy remain uninvestigated, this study was done to determine biological activities such as cytotoxicity, anti-inflammatory and antifungal properties as well as total phenolic contents of ethanolic and aqueous extracts of MRM and its medicinal plant ingredients. Results showed that the ethanolic extract of MRM expressed anti-inflammatory activity against interleukin 6 (IL-6) production and inhibited Candida albicans growth. However, the MRM extract was not toxic to ovarian or uterine cancer cell lines. On the other hand, some ethanolic extracts of some single medicinal plants showed a good cytotoxic activity against ovarian and uterine cancer cell lines. For total phenolic analysis, ethanolic extracts of MRM and its single herbal ingredients had high phenolic contents. The findings indicate that MRM ethanolic extract has anti-inflammatory and antifungal activities, but does not inhibit the growth of ovarian or uterine cancer cell lines. Thus, based on its preliminary medicinal property information, MRM can be used as a drug and for further product development. However, other relevant MRM biological activities and safety should be studied in the future.
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